Immunogenetics of seasonal influenza vaccine response

Gregory A. Poland, Inna G. Ovsyannikova, Robert M. Jacobson

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Seasonal influenza causes significant morbidity, mortality, and economic costs. Vaccines against influenza, though both safe and effective, are imperfect. Notably, these vaccines result in significant immune response variability across the population. The mechanism for this variability, in part, appears to lie in the polymorphisms of key immune response genes. Despite the importance of this variability, little in the way of genetic polymorphisms and its association with vaccine immune response to viral vaccines has been performed. Herein, we review and synthesize what is known about the immune response pathway and influenza viral immunity and then present original data from our laboratory on the immunogenetic relationships between HLA, cytokine and cytokine receptor gene polymorphisms and the variations in humoral immune response to inactivated seasonal influenza vaccine. Finally, we propose that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines.

Original languageEnglish (US)
Pages (from-to)D35-D40
JournalVaccine
Volume26
Issue numberSUPPL. 4
DOIs
StatePublished - Sep 12 2008

Keywords

  • Active immunity
  • Cytokines
  • Cytokines and polymorphism
  • Genetic
  • Genetic predisposition to disease
  • HLA antigens
  • Influenza vaccines
  • Polymorphism
  • Receptors
  • Single nucleotide

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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