Immunogenetics of familial rheumatoid arthritis: A study of 41 multicase families

V. Taneja, N. K. Mehra, R. R. Singh, C. Anand, A. N. Malaviya

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (χ2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalJournal of Rheumatology
Volume20
Issue number2
StatePublished - Jan 1 1993

Keywords

  • HLA haplotypes
  • immunogenetics
  • multicase families
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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