Immunogenetic studies in families of children with juvenile dermatomyositis

Ann M. Reed, Lauren M. Pachman, Jennifer Hayford, Carole Ober

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective. We reported an association between juvenile dermatomyositis (JDMS) and the HLADQA1*0501 allele. The purpose of this study was to determine whether there is evidence for linkage between JDMS and the DQA1*0501 allele in JDMS families. Methods. The study population included 18 unrelated patients with JDMS, their parents, and 49 unaffected siblings. Using molecular genetic techniques, we studied the HLA genes, DRB1, DQA1, and tumor necrosis factor-α. Results. Using the transmission disequilibrium test, we confirmed our earlier observations that the HLA-DQA1*0501 allele confers primary susceptibility to JDMS. Conclusion. DQA1*0501 confers genetic risk for JDMS; we cannot exclude the effects of alleles at other linked loci that were not studied or interactive effects between DQA1 alleles and alleles at other loci.

Original languageEnglish (US)
Pages (from-to)1000-1002
Number of pages3
JournalJournal of Rheumatology
Volume25
Issue number5
StatePublished - May 1998
Externally publishedYes

Fingerprint

Immunogenetics
Alleles
Genetic Techniques
HLA-DRB1 Chains
Juvenile dermatomyositis
Siblings
Molecular Biology
Tumor Necrosis Factor-alpha
Parents
Population
Genes

Keywords

  • HLA
  • Juvenile dermatomyositis
  • MHC antigens
  • Polymyositis/dermatomyositis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Reed, A. M., Pachman, L. M., Hayford, J., & Ober, C. (1998). Immunogenetic studies in families of children with juvenile dermatomyositis. Journal of Rheumatology, 25(5), 1000-1002.

Immunogenetic studies in families of children with juvenile dermatomyositis. / Reed, Ann M.; Pachman, Lauren M.; Hayford, Jennifer; Ober, Carole.

In: Journal of Rheumatology, Vol. 25, No. 5, 05.1998, p. 1000-1002.

Research output: Contribution to journalArticle

Reed, AM, Pachman, LM, Hayford, J & Ober, C 1998, 'Immunogenetic studies in families of children with juvenile dermatomyositis', Journal of Rheumatology, vol. 25, no. 5, pp. 1000-1002.
Reed AM, Pachman LM, Hayford J, Ober C. Immunogenetic studies in families of children with juvenile dermatomyositis. Journal of Rheumatology. 1998 May;25(5):1000-1002.
Reed, Ann M. ; Pachman, Lauren M. ; Hayford, Jennifer ; Ober, Carole. / Immunogenetic studies in families of children with juvenile dermatomyositis. In: Journal of Rheumatology. 1998 ; Vol. 25, No. 5. pp. 1000-1002.
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