Immunogenetic control of the intestinal microbiota

Eric Marietta, Abdul Rishi, Veena D Taneja

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

All vertebrates contain a diverse collection of commensal, symbiotic and pathogenic microorganisms, such as bacteria, viruses and fungi, on their various body surfaces, and the ecological community of these microorganisms is referred to as the microbiota. Mucosal sites, such as the intestine, harbour the majority of microorganisms, and the human intestine contains the largest community of commensal and symbiotic bacteria. This intestinal community of bacteria is diverse, and there is a significant variability among individuals with respect to the composition of the intestinal microbiome. Both genetic and environmental factors can influence the diversity and composition of the intestinal bacteria with the predominant environmental factor being diet. So far, studies have shown that diet-dependent differences in the composition of intestinal bacteria can be classified into three groups, called enterotypes. Other environmental factors that can influence the composition include antibiotics, probiotics, smoking and drugs. Studies of monozygotic and dizygotic twins have proven that genetics plays a role. Recently, MHC II genes have been associated with specific microbial compositions in human infants and transgenic mice that express different HLA alleles. There is a growing list of genes/molecules that are involved with the sensing and monitoring of the intestinal lumen by the intestinal immune system that, when genetically altered, will significantly alter the composition of the intestinal microflora. The focus of this review will be on the genetic factors that influence the composition of the intestinal microflora.

Original languageEnglish (US)
Pages (from-to)313-322
Number of pages10
JournalImmunology
Volume145
Issue number3
DOIs
StatePublished - Jul 1 2015

Fingerprint

Immunogenetics
Bacteria
Diet
Dizygotic Twins
Biota
Monozygotic Twins
Microbiota
Large Intestine
Probiotics
Transgenic Mice
Genes
Intestines
Vertebrates
Immune System
Fungi
Smoking
Alleles
Gastrointestinal Microbiome
Anti-Bacterial Agents
Viruses

Keywords

  • Arthritis
  • HLA
  • Immunogenetic
  • Intestine
  • Microbiome

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Immunogenetic control of the intestinal microbiota. / Marietta, Eric; Rishi, Abdul; Taneja, Veena D.

In: Immunology, Vol. 145, No. 3, 01.07.2015, p. 313-322.

Research output: Contribution to journalArticle

Marietta, Eric ; Rishi, Abdul ; Taneja, Veena D. / Immunogenetic control of the intestinal microbiota. In: Immunology. 2015 ; Vol. 145, No. 3. pp. 313-322.
@article{0f88628829de4d1e8a3a3d0b679ff45b,
title = "Immunogenetic control of the intestinal microbiota",
abstract = "All vertebrates contain a diverse collection of commensal, symbiotic and pathogenic microorganisms, such as bacteria, viruses and fungi, on their various body surfaces, and the ecological community of these microorganisms is referred to as the microbiota. Mucosal sites, such as the intestine, harbour the majority of microorganisms, and the human intestine contains the largest community of commensal and symbiotic bacteria. This intestinal community of bacteria is diverse, and there is a significant variability among individuals with respect to the composition of the intestinal microbiome. Both genetic and environmental factors can influence the diversity and composition of the intestinal bacteria with the predominant environmental factor being diet. So far, studies have shown that diet-dependent differences in the composition of intestinal bacteria can be classified into three groups, called enterotypes. Other environmental factors that can influence the composition include antibiotics, probiotics, smoking and drugs. Studies of monozygotic and dizygotic twins have proven that genetics plays a role. Recently, MHC II genes have been associated with specific microbial compositions in human infants and transgenic mice that express different HLA alleles. There is a growing list of genes/molecules that are involved with the sensing and monitoring of the intestinal lumen by the intestinal immune system that, when genetically altered, will significantly alter the composition of the intestinal microflora. The focus of this review will be on the genetic factors that influence the composition of the intestinal microflora.",
keywords = "Arthritis, HLA, Immunogenetic, Intestine, Microbiome",
author = "Eric Marietta and Abdul Rishi and Taneja, {Veena D}",
year = "2015",
month = "7",
day = "1",
doi = "10.1111/imm.12474",
language = "English (US)",
volume = "145",
pages = "313--322",
journal = "Immunology",
issn = "0019-2805",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Immunogenetic control of the intestinal microbiota

AU - Marietta, Eric

AU - Rishi, Abdul

AU - Taneja, Veena D

PY - 2015/7/1

Y1 - 2015/7/1

N2 - All vertebrates contain a diverse collection of commensal, symbiotic and pathogenic microorganisms, such as bacteria, viruses and fungi, on their various body surfaces, and the ecological community of these microorganisms is referred to as the microbiota. Mucosal sites, such as the intestine, harbour the majority of microorganisms, and the human intestine contains the largest community of commensal and symbiotic bacteria. This intestinal community of bacteria is diverse, and there is a significant variability among individuals with respect to the composition of the intestinal microbiome. Both genetic and environmental factors can influence the diversity and composition of the intestinal bacteria with the predominant environmental factor being diet. So far, studies have shown that diet-dependent differences in the composition of intestinal bacteria can be classified into three groups, called enterotypes. Other environmental factors that can influence the composition include antibiotics, probiotics, smoking and drugs. Studies of monozygotic and dizygotic twins have proven that genetics plays a role. Recently, MHC II genes have been associated with specific microbial compositions in human infants and transgenic mice that express different HLA alleles. There is a growing list of genes/molecules that are involved with the sensing and monitoring of the intestinal lumen by the intestinal immune system that, when genetically altered, will significantly alter the composition of the intestinal microflora. The focus of this review will be on the genetic factors that influence the composition of the intestinal microflora.

AB - All vertebrates contain a diverse collection of commensal, symbiotic and pathogenic microorganisms, such as bacteria, viruses and fungi, on their various body surfaces, and the ecological community of these microorganisms is referred to as the microbiota. Mucosal sites, such as the intestine, harbour the majority of microorganisms, and the human intestine contains the largest community of commensal and symbiotic bacteria. This intestinal community of bacteria is diverse, and there is a significant variability among individuals with respect to the composition of the intestinal microbiome. Both genetic and environmental factors can influence the diversity and composition of the intestinal bacteria with the predominant environmental factor being diet. So far, studies have shown that diet-dependent differences in the composition of intestinal bacteria can be classified into three groups, called enterotypes. Other environmental factors that can influence the composition include antibiotics, probiotics, smoking and drugs. Studies of monozygotic and dizygotic twins have proven that genetics plays a role. Recently, MHC II genes have been associated with specific microbial compositions in human infants and transgenic mice that express different HLA alleles. There is a growing list of genes/molecules that are involved with the sensing and monitoring of the intestinal lumen by the intestinal immune system that, when genetically altered, will significantly alter the composition of the intestinal microflora. The focus of this review will be on the genetic factors that influence the composition of the intestinal microflora.

KW - Arthritis

KW - HLA

KW - Immunogenetic

KW - Intestine

KW - Microbiome

UR - http://www.scopus.com/inward/record.url?scp=84931575619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931575619&partnerID=8YFLogxK

U2 - 10.1111/imm.12474

DO - 10.1111/imm.12474

M3 - Article

C2 - 25913295

AN - SCOPUS:84931575619

VL - 145

SP - 313

EP - 322

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - 3

ER -