Immunodominance in the immune response to 'multiple' histocompatibility antigens

P. J. Wettstein, D. W. Bailey

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2(d) mice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a panel of targets whose BALB/c-derived non-H-2-H antigens were donated by CXB recombinant inbred mice. The spectrum of reactivity of cytotoxic effector T cells with CXB targets demonstrated that the effectors did not recognize multiple H antigens but rather preferentially recognized a single immunodominant non-H-2 H antigen. The identity of the immunodominant H antigen was determined by the H-2 genotype of the stimulator cells when (B6 x B6.C-H-2(d))F1 cytotoxic effectors were tested. These observations indicate that despite the fact that responders were challenged with more than 40 individual non-H-2H antigens, they preferentially responded to a single immunodominant antigen.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalImmunogenetics
Volume16
Issue number1
StatePublished - 1982
Externally publishedYes

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Histocompatibility Antigens
H-2 Antigens
Immunodominant Epitopes
T-Lymphocytes
Genotype
Antigens
H antigen

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Immunodominance in the immune response to 'multiple' histocompatibility antigens. / Wettstein, P. J.; Bailey, D. W.

In: Immunogenetics, Vol. 16, No. 1, 1982, p. 47-58.

Research output: Contribution to journalArticle

Wettstein, PJ & Bailey, DW 1982, 'Immunodominance in the immune response to 'multiple' histocompatibility antigens', Immunogenetics, vol. 16, no. 1, pp. 47-58.
Wettstein, P. J. ; Bailey, D. W. / Immunodominance in the immune response to 'multiple' histocompatibility antigens. In: Immunogenetics. 1982 ; Vol. 16, No. 1. pp. 47-58.
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