Immunodominance in the immune response to "multiple" histocompatibility antigens

Peter J. Wettstein, Donald W. Bailey

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2dmice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a panel of targets whose BALB/c-derived non-H-2 H antigens were donated by CXB recombinant inbred mice. The spectrum of reactivity of cytotoxic effector T cells with CXB targets demonstrated that the effectors did not recognize multiple H antigens but rather preferentially recognized a single immunodominant non-H-2 H antigen. The identity of the immunodominant H antigen was determined by the H-2 genotype of the stimulator cells when (B6 × B6.C-H-2d)F1 cytotoxic effectors were tested. These observations indicate that despite the fact that responders were challenged with more than 40 individual non-H-2 H antigens, they preferentially responded to a single immunodominant antigen.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalImmunogenetics
Volume16
Issue number1
DOIs
StatePublished - Jul 1982

ASJC Scopus subject areas

  • Immunology
  • Genetics

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