Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism

S. H. Yen, D. S. Horoupian, R. D. Terry

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Antiserum raised against a two-cycle-purified human brain mictotubule fraction that binds specifically to tangles of senile dementia of the Alzheimer type was tested on the subthalamus, basis pontis, and midbrain sections of two patients with progressive supranuclear palsy. Tangles composed of 15 nm straight fibers in these areas showed positive immunolabeling with the antiserum. The labeling tangles appeared as a fibrous meshwork in neuronal cell bodies and occasionally in short segments of axons. Corresponding sections of brains obtained from patients with idiopathic parkinsonism, striatonigral degeneration, and olivopontocerebellar atrophy treated with the same antiserum did not display peoxidase products. Only in the elderly subjects and patients with postencephalitic parkinsonism did the periaqueductal gray and median raphe show occasional cells that reacted positively with the antiserum. Tangles in the substantia nigra of patients with postencephalitic parkinsonism were also recognized by the antiserum. The results suggest that the two morphologically distinct neurofibrillary tangles share their immunological properties with components present in microtubule fractions of normal brain.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalAnnals of Neurology
Volume13
Issue number2
StatePublished - 1983
Externally publishedYes

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Postencephalitic Parkinson Disease
Progressive Supranuclear Palsy
Neurofibrillary Tangles
Immune Sera
Alzheimer Disease
Striatonigral Degeneration
Brain
Olivopontocerebellar Atrophies
Subthalamus
Periaqueductal Gray
Parkinsonian Disorders
Substantia Nigra
Mesencephalon
Microtubules
Axons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Immunocytochemical comparison of neurofibrillary tangles in senile dementia of Alzheimer type, progressive supranuclear palsy, and postencephalitic parkinsonism. / Yen, S. H.; Horoupian, D. S.; Terry, R. D.

In: Annals of Neurology, Vol. 13, No. 2, 1983, p. 172-175.

Research output: Contribution to journalArticle

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