Immunity in esophageal carcinoma

S. H. Advani, P. M. Kutty, R. Gopal, S. Swaroop, C. N. Nair, K. A. Dinshaw, S. R. Damle, J. S. Nadkarni, P. N. Akolkar, B. P. Gothaskar, J. J. Vyas, P. B. Desai

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In carcinoma of the esophagus, response to in vivo sensitization with recall antigens and DNCB was markedly depressed with 13% and 16% positivity respectively. Similarly, the number of T‐cells was found to be significantly low (24 ± 14) as compared to normal control (61 ± 23). Blastogenesis index with PHA was only 1.75 ± 1.04 in contrast to normal of 6.79 ± 2.57. This depression was independent of serum albumin level and body weight. Cell‐mediated immunity was further depressed following radiotherapy and did not improve following enteral alimentation for 3 weeks. In untreated patients, there was a significant rise in levels of IgA (298 ± 184 mg/100 ml) as compared to normal (154 ± 54 mg/100 ml). Levels of IgA did show a downward trend following enteral hyperalimentation. Circulating immune complexes and serum CEA level were elevated in almost 50% of patients. These data confirm the influence of tumor‐related impairment of cell‐mediated immunity while nutrition appears to affect IgA levels.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalJournal of Surgical Oncology
Volume24
Issue number4
DOIs
StatePublished - Dec 1983

Keywords

  • esophageal cancer
  • immune response

ASJC Scopus subject areas

  • Surgery
  • Oncology

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