Immunity and cognition

what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?

Jonathan Kipnis, Noel Christopher Derecki, Chunhui Yang, Heidi Scrable

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Until recently, dogma dictated that the immune system and the central nervous system (CNS) live mostly separate, parallel lives, and any interactions between the two were assumed to be limited to extreme cases of pathological insult. It was only a decade ago that T cells in the injured brain were shown to play a protective rather than a destructive role. In this article, we explore the role of the immune system in the healthy brain, focusing on the key function that T lymphocytes have in the regulation of cognition. We discuss candidate mechanisms underlying T cell-mediated control of cognitive function in human cognitive diseases associated with immune decline, such as age- and HIV-related dementias, 'chemo-brain' and others.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalTrends in Immunology
Volume29
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

AIDS Dementia Complex
Cognition
Dementia
Immunity
T-Lymphocytes
Immune System
Brain
Central Nervous System

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunity and cognition : what do age-related dementia, HIV-dementia and 'chemo-brain' have in common? / Kipnis, Jonathan; Derecki, Noel Christopher; Yang, Chunhui; Scrable, Heidi.

In: Trends in Immunology, Vol. 29, No. 10, 10.2008, p. 455-463.

Research output: Contribution to journalArticle

Kipnis, Jonathan ; Derecki, Noel Christopher ; Yang, Chunhui ; Scrable, Heidi. / Immunity and cognition : what do age-related dementia, HIV-dementia and 'chemo-brain' have in common?. In: Trends in Immunology. 2008 ; Vol. 29, No. 10. pp. 455-463.
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