Immune response–associated antigens on mouse leukemia cells: II. anti–ia sera inhibit the MLR reaction between normal GR spleen cells and syngeneic spleen cells of GRSL tumor–bearing mice

Kenji Okuda, Brian C. Neely, J. O. Hilgers, Chella S. David

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Mitomycin C-treated ascites cells of Ia antigen-positive GRSL14 tumor cells and spleen cells from GRSL14 tumor-bearing mice stimulated lymphocyte proliferative responses in normal syngeneic GR spleen cells. Furthermore, mitomycin C-treated T cells purified from spleen cells of tumor-bearing mice also stimulated normal GR spleen cells. Anti-la sera inhibited the stimulating ability of tumor cells and of spleen cells of tumor-bearing mice. These data suggest a role for I region gene products in immune surveillance for syngeneic tumors.

Original languageEnglish (US)
Pages (from-to)300-303
Number of pages4
JournalTransplantation
Volume26
Issue number5
DOIs
StatePublished - Nov 1978

ASJC Scopus subject areas

  • Transplantation

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