The genetically controlled immune response to calf skin collagen type I in mice could be demonstrated to be governed by at least two genes. One is linked to the H-2 complex and located within the IA subregion. High-responder alleles are H-2b, H-2f, and H-2s. The other gene(s) is not linked to the H-2 complex and high-responder allele(s) are found in the genome of B10 mice but not in the genome of DBA mice. There are strong indications that the Ir-1A gene controls the response at the T-cell level, whereas it is assumed that the background gene(s) control the immune response at a different level.
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