Immune response to calf collagen type I in mice: A combined control of Ir-1A and non H-2 linked genes

Hans Nowack, Eckhart Hahn, Chella S. David, Rupert Timpl, Dietrich Götze

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The genetically controlled immune response to calf skin collagen type I in mice could be demonstrated to be governed by at least two genes. One is linked to the H-2 complex and located within the IA subregion. High-responder alleles are H-2b, H-2f, and H-2s. The other gene(s) is not linked to the H-2 complex and high-responder allele(s) are found in the genome of B10 mice but not in the genome of DBA mice. There are strong indications that the Ir-1A gene controls the response at the T-cell level, whereas it is assumed that the background gene(s) control the immune response at a different level.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalImmunogenetics
Volume2
Issue number1
DOIs
StatePublished - Dec 1975

ASJC Scopus subject areas

  • Immunology
  • Genetics

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