Immune response: Glioma-associated immunosuppression

Selby Chen, Ian F Parney

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Gliomas such as glioblastoma have a complex relationship with the immune system. Glioblastomas have a harshly immunosuppressive microenvironment due in large part to the expression of multiple factors by tumor cells that inhibit T-cell responses. In addition, glioblastomas are heavily infiltrated with monocytic cells. These cells appear to have become immunosuppressive under the influence of the tumor and share characteristics with myeloid-derived suppressor cells. To a lesser degree, gliomas have T-cell infiltrates. Similarly, these largely appear to have adopted the immunosuppressive phenotype of regulatory T cells. Glioblastoma patients also have marked systemic immunosuppression characterized by globally reduced T-cell counts and impaired T-cell function coupled with increased circulating immunosuppressive regulatory T cells and myeloid-derived suppressor cells. The relationships between these various immunosuppressive cell populations, their impact on T cells, and their implications for immunotherapies are reviewed in this chapter.

Original languageEnglish (US)
Title of host publicationGlioma Cell Biology
PublisherSpringer-Verlag Wien
Pages221-239
Number of pages19
Volume9783709114315
ISBN (Print)9783709114315, 3709114306, 9783709114308
DOIs
StatePublished - Sep 1 2012

Keywords

  • Glioma
  • Immunosuppression
  • Myeloid-derived suppressor cell
  • Regulatory T cell

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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  • Cite this

    Chen, S., & Parney, I. F. (2012). Immune response: Glioma-associated immunosuppression. In Glioma Cell Biology (Vol. 9783709114315, pp. 221-239). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1431-5_8