Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination

M. Rodriguez, M. L. Pierce, E. A. Howie

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Abstract

Theiler's murine encephalomyelitis virus induced central nervous system demyelination in susceptible strains of mice with s, q, v, p, and f H-2D alleles. We used immunoelectron microscopy to look for differential production of class I immune response gene products (Ia) within astrocytes, oligodendrocytes, microglia, and endothelial cells. Spinal cord sections from susceptible mice (B10.S and B10.ASR2) showed increased content of Ia in glial and endothelial cells. In contrast, resistant mice [B10.S(9R)] showed minimal Ia production within the CNS. The findings indicate an important role of class II immune response products on glial cells during demyelination after virus infection.

Original languageEnglish (US)
Pages (from-to)3438-3442
Number of pages5
JournalJournal of Immunology
Volume138
Issue number10
StatePublished - Jan 1 1987

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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