Immune regulation of immunoglobulin production in IgA-nephropathy

Fernando G. Cosio; Sylvia Lam; Ayoola O. Folami; Mary Ellen Conley; Alfred F. Michael

doi:10.1016/0090-1229(82)90127-1

Immune regulation of immunoglobulin production in IgA-nephropathy

Fernando G. Cosio, Sylvia Lam, Ayoola O. Folami, Mary Ellen Conley, Alfred F. Michael

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA₁ and IgA₂ were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.

Original language	English (US)
Pages (from-to)	430-436
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(82)90127-1
State	Published - May 1982

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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title = "Immune regulation of immunoglobulin production in IgA-nephropathy",

abstract = "Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.",

author = "Cosio, {Fernando G.} and Sylvia Lam and Folami, {Ayoola O.} and Conley, {Mary Ellen} and Michael, {Alfred F.}",

note = "Funding Information: * This article is dedicated to Robert A. Good on the occasion of his 60th birthday. 1T his work was aided by grants from the National Institutes of Health (AI10704 and AM25518). the Minnesota Medical Foundation (KRF-2-81), the Arthritis Foundation, and the Minnesota Vikings Children{\textquoteright}s Fund. * Department of Pediatrics, University College Hospital, Ibadan, Nigeria, West Africa. 3 Department of Immunology, Children{\textquoteright}s Hospital, Philadelphia, Pennsylvania.",

year = "1982",

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doi = "10.1016/0090-1229(82)90127-1",

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AU - Lam, Sylvia

AU - Folami, Ayoola O.

AU - Conley, Mary Ellen

AU - Michael, Alfred F.

N1 - Funding Information: * This article is dedicated to Robert A. Good on the occasion of his 60th birthday. 1T his work was aided by grants from the National Institutes of Health (AI10704 and AM25518). the Minnesota Medical Foundation (KRF-2-81), the Arthritis Foundation, and the Minnesota Vikings Children’s Fund. * Department of Pediatrics, University College Hospital, Ibadan, Nigeria, West Africa. 3 Department of Immunology, Children’s Hospital, Philadelphia, Pennsylvania.

PY - 1982/5

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N2 - Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.

AB - Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.

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Immune regulation of immunoglobulin production in IgA-nephropathy

Abstract

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