Abstract
Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 430-436 |
| Number of pages | 7 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1982 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Immune regulation of immunoglobulin production in IgA-nephropathy. / Cosio, Fernando G; Lam, Sylvia; Folami, Ayoola O.; Conley, Mary Ellen; Michael, Alfred F.
In: Clinical Immunology and Immunopathology, Vol. 23, No. 2, 1982, p. 430-436.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune regulation of immunoglobulin production in IgA-nephropathy
AU - Cosio, Fernando G
AU - Lam, Sylvia
AU - Folami, Ayoola O.
AU - Conley, Mary Ellen
AU - Michael, Alfred F.
PY - 1982
Y1 - 1982
N2 - Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.
AB - Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.
UR - http://www.scopus.com/inward/record.url?scp=0019972960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019972960&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(82)90127-1
DO - 10.1016/0090-1229(82)90127-1
M3 - Article
VL - 23
SP - 430
EP - 436
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 2
ER -