Immune regulation of immunoglobulin production in IgA-nephropathy

Fernando G. Cosio, Sylvia Lam, Ayoola O. Folami, Mary Ellen Conley, Alfred F. Michael

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Serum immunoglobulin concentrations, percentage surface IgA-positive peripheral blood lymphocytes, and PWM- and Con A-stimulated immunoglobulin production in vitro were evaluated in patients with IgA nephropathy and normal controls. Elevated levels of serum IgA and IgM were present in 46 and 62% of patients, respectively, but the absolute concentrations of IgA1 and IgA2 were not different from normal values. In comparison with controls, patients with IgA nephropathy demonstrated similar numbers of surface IgG- and IgA-positive peripheral blood lymphocytes and after stimulation with PWM and Con A their lymphocytes produced similar amounts of IgG, IgA, and IgM. Separate analysis of a subgroup of patients with severe disease demonstrated significantly higher IgG and IgM production after PWM stimulation. However, serum immunoglobulin levels were not different. The number of Ig-bearing lymphocytes and the in vitro production of IgA is normal in IgA nephropathy. Excessive production of IgG and IgM in vitro is limited to patients with severe disease.

Original languageEnglish (US)
Pages (from-to)430-436
Number of pages7
JournalClinical Immunology and Immunopathology
Issue number2
StatePublished - May 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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