Immune modulation and immune-mediated pathogenesis of emerging tickborne banyangviruses

Crystal A. Mendoza, Hideki Ebihara, Satoko Yamaoka

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In the last decade, the emergence of several, novel tickborne viruses have caused significant disease in humans. Of interest are the tickborne banyangviruses: Severe fever with thrombocytopenia syndrome virus (SFTSV), Heartland virus (HRTV), and Guertu virus (GTV). SFTSV and HRTV infection in humans cause viral hemorrhagic fever-like disease leading to mortality rates ranging from 6-30% of the cases. The systemic inflammatory response syndrome (SIRS) associated with SFTSV infection is hypothesized to contribute significantly to pathology seen in patients. Despite the severe disease caused by HRTV and SFTSV, there are no approved therapeutics or vaccines. Investigation of the immune response during and following infection is critical to the generation of fully protective vaccines and/or supportive treatments, and overall understanding of viral immune evasion mechanisms may aid in the development of a new class of therapeutics.

Original languageEnglish (US)
Article number125
JournalVaccines
Volume7
Issue number4
DOIs
StatePublished - Dec 2019

Keywords

  • Banyangvirus
  • Guertu virus
  • Heartland
  • HRTV
  • Interferon antagonism
  • Severe fever with thrombocytopenia syndrome virus
  • SFTS
  • SFTSV

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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