Abstract
Epigenetic reprogramming is a hallmark of lymphomagenesis, however its role in reshaping the tumor microenvironment is still not well understood. Here we review the most common chromatin modifier mutations in B cell lymphoma and their effect on B cells as well as on T cell landscape. We will also discuss precision therapy strategies to reverse their aberrant signaling by targeting mutated proteins or counterbalance epigenetic mechanisms.
Original language | English (US) |
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Article number | 826594 |
Journal | Frontiers in Genetics |
Volume | 13 |
DOIs | |
State | Published - Feb 14 2022 |
Keywords
- B cell lymphoma
- T cells
- diffuse large B cell lymphoma
- epigenetics
- follicular lymphoma
- immune crosstalk
- tumor microenvironment
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Genetics(clinical)