Immune Epigenetic Crosstalk Between Malignant B Cells and the Tumor Microenvironment in B Cell Lymphoma

Research output: Contribution to journalReview articlepeer-review

Abstract

Epigenetic reprogramming is a hallmark of lymphomagenesis, however its role in reshaping the tumor microenvironment is still not well understood. Here we review the most common chromatin modifier mutations in B cell lymphoma and their effect on B cells as well as on T cell landscape. We will also discuss precision therapy strategies to reverse their aberrant signaling by targeting mutated proteins or counterbalance epigenetic mechanisms.

Original languageEnglish (US)
Article number826594
JournalFrontiers in Genetics
Volume13
DOIs
StatePublished - Feb 14 2022

Keywords

  • B cell lymphoma
  • T cells
  • diffuse large B cell lymphoma
  • epigenetics
  • follicular lymphoma
  • immune crosstalk
  • tumor microenvironment

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

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