Immune-complex deposits in "pauci-immune" glomerulonephritis: A case report and brief review of recent literature

Mireille El-Ters, Umadevi Muthyala, Marie D. Philipneri, Fadi A. Hussein, Krista L. Lentine

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is considered a "pauci-immune" disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. We describe a 72-year-old man with progressive renal failure over five months who was found to have P-ANCA associated crescentic glomerulonephritis. Renal biopsy also revealed immunofluorescence staining for Immunoglobulin G and C3. Treatment comprised corticosteroids, cyclophosphamide, and plasmapheresis but unfortunately kidney function did not recover, likely due to substantial interstitial fibrosis at diagnosis. This case illustrates that serologic evaluation for ANCAs should not be discounted when immune deposits are present. Prompt diagnosis is warranted.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalArchives of Medical Science
Volume6
Issue number4
DOIs
StatePublished - Aug 1 2010

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Keywords

  • Anti-neutrophil cytoplasmic antibodies
  • Glomerulonephritis
  • Immune deposits

ASJC Scopus subject areas

  • Medicine(all)

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