Immune checkpoint blockade in lymphoid malignancies

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Malignant cells may subvert and escape endogenous host immune surveillance by up-regulation of immune inhibitory signals known as immune checkpoints. These checkpoints are important therapeutic targets, and antibodies that block checkpoint signaling have shown remarkable efficacy in some solid tumors as well as in some refractory hematologic malignancies. In hematologic cancers, the mechanism of these checkpoints is complex, as the tumor and immune system are one and the same. In this review, we evaluate the biology of checkpoint inhibition, review the current data on its efficacy in lymphoid tumors, and explore uncertainties in the field, including those involving the precise mechanisms of action, the appropriate timing of therapy, and the differences in response rate between lymphoid tumor types.

Original languageEnglish (US)
Pages (from-to)2233-2244
Number of pages12
JournalThe FEBS journal
Volume283
Issue number12
DOIs
StatePublished - Jun 1 2016

Keywords

  • biology
  • CTLA4
  • Hodgkin lymphoma
  • immune checkpoint
  • immunotherapy
  • myeloma
  • non-Hodgkin lymphoma
  • PD-1
  • therapy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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