TY - JOUR
T1 - Immune cell crosstalk in obesity
T2 - A key role for costimulation?
AU - Seijkens, Tom
AU - Kusters, Pascal
AU - Chatzigeorgiou, Antonios
AU - Chavakis, Triantafyllos
AU - Lutgens, Esther
N1 - Publisher Copyright:
© 2014 by the American Diabetes Association. Readers.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflammatory processes in metabolic organs, such as the adipose tissue (AT) and liver, thereby mediating obesity-related metabolic deterioration. Costimulatory molecules, which are present on antigenpresenting cells and naïve T cells in the AT, are known to mediate the crosstalk between the adaptive and innate immune system and to direct T-cell responses in inflammation. In this Perspectives in Diabetes article, we highlight the newest insights in immune cell interactions in obesity and discuss the role of costimulatory dyads in its pathogenesis. Moreover, the potential of therapeutic strategies that target costimulatory molecules in the metabolic syndrome is explored.
AB - In the past two decades, numerous experimental and clinical studies have established the importance of inflammation and immunity in the development of obesity and its metabolic complications, including insulin resistance and type 2 diabetes mellitus. In this context, T cells orchestrate inflammatory processes in metabolic organs, such as the adipose tissue (AT) and liver, thereby mediating obesity-related metabolic deterioration. Costimulatory molecules, which are present on antigenpresenting cells and naïve T cells in the AT, are known to mediate the crosstalk between the adaptive and innate immune system and to direct T-cell responses in inflammation. In this Perspectives in Diabetes article, we highlight the newest insights in immune cell interactions in obesity and discuss the role of costimulatory dyads in its pathogenesis. Moreover, the potential of therapeutic strategies that target costimulatory molecules in the metabolic syndrome is explored.
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U2 - 10.2337/db14-0272
DO - 10.2337/db14-0272
M3 - Article
C2 - 25414012
AN - SCOPUS:84911891418
SN - 0012-1797
VL - 63
SP - 3982
EP - 3991
JO - Diabetes
JF - Diabetes
IS - 12
ER -