Immune-based monitoring for cytomegalovirus infection in solid organ transplantation: Is it ready for clinical primetime?

Dante Melendez, Raymund R Razonable

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The impact of CMV infection and disease in solid organ transplant (SOT) recipients continues despite remarkable improvements in its prevention and management with antiviral drugs. Studies that have investigated the host immune response to CMV have paved way for the development of novel immune-based assays that are anticipated to complement the current antiviral-based strategies for CMV management after transplantation. In this article, we review the emerging data on the clinical application of innovative CMV-specific T-cell assays, including their role in risk-stratification, prognostication, prevention and treatment of CMV infection and disease in SOT recipients.

Original languageEnglish (US)
Pages (from-to)1213-1227
Number of pages15
JournalExpert Review of Clinical Immunology
Volume10
Issue number9
DOIs
StatePublished - 2014

Fingerprint

Immunologic Monitoring
Cytomegalovirus Infections
Organ Transplantation
Antiviral Agents
Transplants
Infection
Transplantation
T-Lymphocytes
Transplant Recipients
Therapeutics

Keywords

  • clinical disease
  • CMV
  • immunity
  • relapse
  • risk factors
  • transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Medicine(all)

Cite this

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abstract = "The impact of CMV infection and disease in solid organ transplant (SOT) recipients continues despite remarkable improvements in its prevention and management with antiviral drugs. Studies that have investigated the host immune response to CMV have paved way for the development of novel immune-based assays that are anticipated to complement the current antiviral-based strategies for CMV management after transplantation. In this article, we review the emerging data on the clinical application of innovative CMV-specific T-cell assays, including their role in risk-stratification, prognostication, prevention and treatment of CMV infection and disease in SOT recipients.",
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