Immune-based monitoring for cytomegalovirus infection in solid organ transplantation: Is it ready for clinical primetime?

Dante Melendez; Raymund R. Razonable

doi:10.1586/1744666X.2014.943190

Immune-based monitoring for cytomegalovirus infection in solid organ transplantation: Is it ready for clinical primetime?

Dante Melendez, Raymund R. Razonable

Infectious Diseases

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The impact of CMV infection and disease in solid organ transplant (SOT) recipients continues despite remarkable improvements in its prevention and management with antiviral drugs. Studies that have investigated the host immune response to CMV have paved way for the development of novel immune-based assays that are anticipated to complement the current antiviral-based strategies for CMV management after transplantation. In this article, we review the emerging data on the clinical application of innovative CMV-specific T-cell assays, including their role in risk-stratification, prognostication, prevention and treatment of CMV infection and disease in SOT recipients.

Original language	English (US)
Pages (from-to)	1213-1227
Number of pages	15
Journal	Expert review of clinical immunology
Volume	10
Issue number	9
DOIs	https://doi.org/10.1586/1744666X.2014.943190
State	Published - Sep 2014

Keywords

CMV
clinical disease
immunity
relapse
risk factors
transplantation

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1586/1744666X.2014.943190

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title = "Immune-based monitoring for cytomegalovirus infection in solid organ transplantation: Is it ready for clinical primetime?",

abstract = "The impact of CMV infection and disease in solid organ transplant (SOT) recipients continues despite remarkable improvements in its prevention and management with antiviral drugs. Studies that have investigated the host immune response to CMV have paved way for the development of novel immune-based assays that are anticipated to complement the current antiviral-based strategies for CMV management after transplantation. In this article, we review the emerging data on the clinical application of innovative CMV-specific T-cell assays, including their role in risk-stratification, prognostication, prevention and treatment of CMV infection and disease in SOT recipients.",

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N2 - The impact of CMV infection and disease in solid organ transplant (SOT) recipients continues despite remarkable improvements in its prevention and management with antiviral drugs. Studies that have investigated the host immune response to CMV have paved way for the development of novel immune-based assays that are anticipated to complement the current antiviral-based strategies for CMV management after transplantation. In this article, we review the emerging data on the clinical application of innovative CMV-specific T-cell assays, including their role in risk-stratification, prognostication, prevention and treatment of CMV infection and disease in SOT recipients.

AB - The impact of CMV infection and disease in solid organ transplant (SOT) recipients continues despite remarkable improvements in its prevention and management with antiviral drugs. Studies that have investigated the host immune response to CMV have paved way for the development of novel immune-based assays that are anticipated to complement the current antiviral-based strategies for CMV management after transplantation. In this article, we review the emerging data on the clinical application of innovative CMV-specific T-cell assays, including their role in risk-stratification, prognostication, prevention and treatment of CMV infection and disease in SOT recipients.

KW - CMV

KW - clinical disease

KW - immunity

KW - relapse

KW - risk factors

KW - transplantation

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Immune-based monitoring for cytomegalovirus infection in solid organ transplantation: Is it ready for clinical primetime?

Abstract

Keywords

ASJC Scopus subject areas

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