Immune abnormalities in renal failure and hemodialysis

Neil E. Kay, Leopoldo R. Raij

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Considerable work needs to be done in order to understand the immunosupressive effect of 'uremia' and the lymphocyte changes induced by hemodialysis. For example, the lymphocyte population dynamics can be further defined using monoclonal antibodies specific for lymphocyte subgroups. In vitro assays are available for lymphokine detection (i.e. IL-1, IL-2 which are important for T cell function) and may be correlated with both the clinical state and overall immunobiological status of hemodialyzed patients. The possibility of specifically delineating the extent of the immune system dysfunction in renal failure patients (on or off dialysis) is at hand. With this knowledge it will be possible to manipulate their management so as to minimize function alterations.

Original languageEnglish (US)
Pages (from-to)120-129
Number of pages10
JournalBlood Purification
Volume4
Issue number1-3
DOIs
StatePublished - Jan 1 1986

Keywords

  • Hemodialysis
  • Immune system
  • Uremia

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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