Imaging of Primary Chondrosarcoma

Radiologic-Pathologic Correlation

Mark D. Murphey, Eric A. Walker, Anthony J. Wilson, Mark J. Kransdorf, H. Thomas Temple, Francis H. Gannon

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Chondrosarcoma is a malignant tumor that produces cartilage matrix, and lesions that arise de novo are called primary. Primary chondrosarcoma is the third most common primary malignant tumor of bone, constituting 20%-27% of all primary malignant osseous neoplasms. There are numerous types of primary chondrosarcomas, including conventional intramedullary, clear cell, juxtacortical, myxoid, mesenchymal, extraskeletal, and dedifferentiated. The conventional intramedullary chondrosarcoma is the most frequent type, and it most commonly involves the long bones or pelvis in up to 65% of cases. Although the pathologic appearance varies with specific lesion type, chondrosarcomas grow with lobular type architecture, and these hyaline cartilage nodules demonstrate high water content and peripheral enchondral ossification. Imaging features directly reflect this pathologic appearance, and the various subtypes often show distinctive features. Radiographic findings often suggest the diagnosis of chondrosarcoma because of identification of typical "ring-and-arc" chondroid matrix mineralization (representing the enchondral ossification) and aggressive features of deep endosteal scalloping and soft-tissue extension. These latter features are usually best assessed, as is lesion staging, with computed tomography (CT) or magnetic resonance (MR) imaging. CT is optimal to detect the matrix mineralization, particularly when it is subtle or when the lesion is located in anatomically complex areas. Both CT and MR imaging depict the high water content of these lesions as low attenuation and very high signal intensity with T2-weighting, respectively. Understanding and recognizing the spectrum of appearances of the various types of primary chondrosarcoma allow improved patient assessment and are vital for optimal clinical management including diagnosis, biopsy, staging, treatment, and prognosis.

Original languageEnglish (US)
Pages (from-to)1245-1278
Number of pages34
JournalRadiographics
Volume23
Issue number5
StatePublished - Sep 2003

Fingerprint

Chondrosarcoma
Tomography
Osteogenesis
Magnetic Resonance Imaging
Hyaline Cartilage
Bone and Bones
Neoplasms
Water
Pelvis
Cartilage
Biopsy

Keywords

  • Bone neoplasms, 40.321
  • Bone neoplasms, CT, 40.1211
  • Bone neoplasms, MR, 40.12141
  • Sarcoma, 40.321

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Murphey, M. D., Walker, E. A., Wilson, A. J., Kransdorf, M. J., Temple, H. T., & Gannon, F. H. (2003). Imaging of Primary Chondrosarcoma: Radiologic-Pathologic Correlation. Radiographics, 23(5), 1245-1278.

Imaging of Primary Chondrosarcoma : Radiologic-Pathologic Correlation. / Murphey, Mark D.; Walker, Eric A.; Wilson, Anthony J.; Kransdorf, Mark J.; Temple, H. Thomas; Gannon, Francis H.

In: Radiographics, Vol. 23, No. 5, 09.2003, p. 1245-1278.

Research output: Contribution to journalArticle

Murphey, MD, Walker, EA, Wilson, AJ, Kransdorf, MJ, Temple, HT & Gannon, FH 2003, 'Imaging of Primary Chondrosarcoma: Radiologic-Pathologic Correlation', Radiographics, vol. 23, no. 5, pp. 1245-1278.
Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH. Imaging of Primary Chondrosarcoma: Radiologic-Pathologic Correlation. Radiographics. 2003 Sep;23(5):1245-1278.
Murphey, Mark D. ; Walker, Eric A. ; Wilson, Anthony J. ; Kransdorf, Mark J. ; Temple, H. Thomas ; Gannon, Francis H. / Imaging of Primary Chondrosarcoma : Radiologic-Pathologic Correlation. In: Radiographics. 2003 ; Vol. 23, No. 5. pp. 1245-1278.
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