TY - JOUR
T1 - Imaging of cerebral activation at 1.5 T
T2 - Otimizing a technique for conventional hardware
AU - Thompson, Richard M.
AU - Jack, Clifford R.
AU - Butts, Kim
AU - Hanson, Dennis P.
AU - Riederer, Stephen J.
AU - Ehman, Richard L.
AU - Hynes, Roger W.
AU - Hangiandreou, Nicholas J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1994/3
Y1 - 1994/3
N2 - PURPOSE: To empirically optimize a two-dimensional magnetic resonance (MR) imaging technique for detecting changes in signal intensity during cerebral activation with a standard clinical imager. MATERIALS AND METHODS: Visual activation experiments were performed while imaging parameters were manipulated in a serial fashion, to test their effect on the percentage change in signal intensity (PCSI). The parameters tested were section thickness, echo time (TE), field of view (FOV), flip angle, radio-frequency (RF) spoiling, number of readout points, and number of signals averaged. RESULTS: The PCSI for visual activation experiments was typically in the 1%-5% range. The best results were achieved with a small section thickness, long TE, and large FOV. Variations in other acquisition parameters had a negligible influence on the PCSI. CONCLUSION: Good results can be obtained at functional MR imaging with standard 1.5-T hardware. Markedly improved results can be obtained by optimizing several key variables, namely, section thickness, TE, and FOV.
AB - PURPOSE: To empirically optimize a two-dimensional magnetic resonance (MR) imaging technique for detecting changes in signal intensity during cerebral activation with a standard clinical imager. MATERIALS AND METHODS: Visual activation experiments were performed while imaging parameters were manipulated in a serial fashion, to test their effect on the percentage change in signal intensity (PCSI). The parameters tested were section thickness, echo time (TE), field of view (FOV), flip angle, radio-frequency (RF) spoiling, number of readout points, and number of signals averaged. RESULTS: The PCSI for visual activation experiments was typically in the 1%-5% range. The best results were achieved with a small section thickness, long TE, and large FOV. Variations in other acquisition parameters had a negligible influence on the PCSI. CONCLUSION: Good results can be obtained at functional MR imaging with standard 1.5-T hardware. Markedly improved results can be obtained by optimizing several key variables, namely, section thickness, TE, and FOV.
KW - Blood, flow dynamics
KW - Brain ,MR 13.12149
KW - Brain, function
KW - Magnetic resonance (MR), vascular studies, 10.12149
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U2 - 10.1148/radiology.190.3.8115643
DO - 10.1148/radiology.190.3.8115643
M3 - Article
C2 - 8115643
AN - SCOPUS:0028314190
SN - 0033-8419
VL - 190
SP - 873
EP - 877
JO - Radiology
JF - Radiology
IS - 3
ER -