Imaging features of copper deficiency myelopathy: A study of 25 cases

Neeraj Kumar, J. Eric Ahlskog, Christopher J. Klein, John D. Port

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


Acquired copper deficiency presents with a spastic gait and sensory ataxia. Spinal cord magnetic resonance imaging (MRI) in patients with copper deficiency myelopathy may show increased T2 signal, most commonly in the dorsal midline cervical and thoracic cord. These imaging findings may be reversible with normalization of serum copper. The clinical and imaging picture is very similar to the subacute combined degeneration seen in patients with vitamin B12 deficiency. Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
Issue number2
StatePublished - Feb 2006


  • Copper deficiency
  • Cord signal
  • Magnetic resonance
  • Myelopathy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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