Imaging features of copper deficiency myelopathy: A study of 25 cases

Neeraj Kumar; J. Eric Ahlskog; Christopher J. Klein; John D. Port

doi:10.1007/s00234-005-0016-5

Imaging features of copper deficiency myelopathy: A study of 25 cases

Neeraj Kumar, J. Eric Ahlskog, Christopher J. Klein, John D. Port

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

Acquired copper deficiency presents with a spastic gait and sensory ataxia. Spinal cord magnetic resonance imaging (MRI) in patients with copper deficiency myelopathy may show increased T2 signal, most commonly in the dorsal midline cervical and thoracic cord. These imaging findings may be reversible with normalization of serum copper. The clinical and imaging picture is very similar to the subacute combined degeneration seen in patients with vitamin B12 deficiency. Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified.

Original language	English (US)
Pages (from-to)	78-83
Number of pages	6
Journal	Neuroradiology
Volume	48
Issue number	2
DOIs	https://doi.org/10.1007/s00234-005-0016-5
State	Published - Feb 2006

Keywords

Copper deficiency
Cord signal
Magnetic resonance
Myelopathy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1007/s00234-005-0016-5

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abstract = "Acquired copper deficiency presents with a spastic gait and sensory ataxia. Spinal cord magnetic resonance imaging (MRI) in patients with copper deficiency myelopathy may show increased T2 signal, most commonly in the dorsal midline cervical and thoracic cord. These imaging findings may be reversible with normalization of serum copper. The clinical and imaging picture is very similar to the subacute combined degeneration seen in patients with vitamin B12 deficiency. Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified.",

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AB - Acquired copper deficiency presents with a spastic gait and sensory ataxia. Spinal cord magnetic resonance imaging (MRI) in patients with copper deficiency myelopathy may show increased T2 signal, most commonly in the dorsal midline cervical and thoracic cord. These imaging findings may be reversible with normalization of serum copper. The clinical and imaging picture is very similar to the subacute combined degeneration seen in patients with vitamin B12 deficiency. Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified.

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KW - Cord signal

KW - Magnetic resonance

KW - Myelopathy

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Imaging features of copper deficiency myelopathy: A study of 25 cases

Abstract

Keywords

ASJC Scopus subject areas

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