Imaging elastic properties of biological tissues by low-frequency harmonic vibration

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The elastic properties of soft tissues are closely related to their structure, biological conditions, and pathology. For years, physicians have used palpation as a crude elasticity measurement tool to diagnose diseases in the human body. Based on this simple concept, but using modern technology, several elasticity imaging schemes have been developed during the past two decades. In this paper, we present two elasticity imaging methods that use a low-frequency (Hz to kHz range) harmonic force to excite the tissue. The first method, called magnetic resonance elastography (MRE), uses a phase sensitive magnetic resonance technique to detect tissue motion. Excitation is usually performed with a mechanical actuator on the surface of the body, although other excitation methods are possible. In the second method, called vibro-acoustography, the radiation force from focused ultrasound is used for excitation in a limited region within the tissue. Tissue motion is detected by measuring the acoustic field emitted by the object in response to the vibration. The resulting images in both methods can be related to the dynamics of the object at the excitation frequency. The spatial resolution of MRE and vibro-acoustography images is in the millimeter and sub-millimeter ranges, respectively. Here, we present the theory and physical principles of MRE and vibro-acoustography and describe their performances. We also present results of experiments on various human tissues, including breast, brain, and vessels. Finally, we discuss potential clinical application of these two imaging methods.

Original languageEnglish (US)
Pages (from-to)1503-1518
Number of pages16
JournalProceedings of the IEEE
Volume91
Issue number10
DOIs
StatePublished - Oct 2003

Fingerprint

Magnetic resonance
Tissue
Imaging techniques
Elasticity
Mechanical actuators
Acoustic fields
Pathology
Brain
Ultrasonics
Radiation
Experiments

Keywords

  • Elasticity
  • Elastography
  • Imaging
  • Magnetic resonance imaging (MRI)
  • Radiation force
  • Ribro-acoustography
  • Ultrasound

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

@article{d653c911090c4155872c3ce4efe4d4be,
title = "Imaging elastic properties of biological tissues by low-frequency harmonic vibration",
abstract = "The elastic properties of soft tissues are closely related to their structure, biological conditions, and pathology. For years, physicians have used palpation as a crude elasticity measurement tool to diagnose diseases in the human body. Based on this simple concept, but using modern technology, several elasticity imaging schemes have been developed during the past two decades. In this paper, we present two elasticity imaging methods that use a low-frequency (Hz to kHz range) harmonic force to excite the tissue. The first method, called magnetic resonance elastography (MRE), uses a phase sensitive magnetic resonance technique to detect tissue motion. Excitation is usually performed with a mechanical actuator on the surface of the body, although other excitation methods are possible. In the second method, called vibro-acoustography, the radiation force from focused ultrasound is used for excitation in a limited region within the tissue. Tissue motion is detected by measuring the acoustic field emitted by the object in response to the vibration. The resulting images in both methods can be related to the dynamics of the object at the excitation frequency. The spatial resolution of MRE and vibro-acoustography images is in the millimeter and sub-millimeter ranges, respectively. Here, we present the theory and physical principles of MRE and vibro-acoustography and describe their performances. We also present results of experiments on various human tissues, including breast, brain, and vessels. Finally, we discuss potential clinical application of these two imaging methods.",
keywords = "Elasticity, Elastography, Imaging, Magnetic resonance imaging (MRI), Radiation force, Ribro-acoustography, Ultrasound",
author = "Mostafa Fatemi and Armando Manduca and Greenleaf, {James F}",
year = "2003",
month = "10",
doi = "10.1109/JPROC.2003.817865",
language = "English (US)",
volume = "91",
pages = "1503--1518",
journal = "Proceedings of the IEEE",
issn = "0018-9219",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "10",

}

TY - JOUR

T1 - Imaging elastic properties of biological tissues by low-frequency harmonic vibration

AU - Fatemi, Mostafa

AU - Manduca, Armando

AU - Greenleaf, James F

PY - 2003/10

Y1 - 2003/10

N2 - The elastic properties of soft tissues are closely related to their structure, biological conditions, and pathology. For years, physicians have used palpation as a crude elasticity measurement tool to diagnose diseases in the human body. Based on this simple concept, but using modern technology, several elasticity imaging schemes have been developed during the past two decades. In this paper, we present two elasticity imaging methods that use a low-frequency (Hz to kHz range) harmonic force to excite the tissue. The first method, called magnetic resonance elastography (MRE), uses a phase sensitive magnetic resonance technique to detect tissue motion. Excitation is usually performed with a mechanical actuator on the surface of the body, although other excitation methods are possible. In the second method, called vibro-acoustography, the radiation force from focused ultrasound is used for excitation in a limited region within the tissue. Tissue motion is detected by measuring the acoustic field emitted by the object in response to the vibration. The resulting images in both methods can be related to the dynamics of the object at the excitation frequency. The spatial resolution of MRE and vibro-acoustography images is in the millimeter and sub-millimeter ranges, respectively. Here, we present the theory and physical principles of MRE and vibro-acoustography and describe their performances. We also present results of experiments on various human tissues, including breast, brain, and vessels. Finally, we discuss potential clinical application of these two imaging methods.

AB - The elastic properties of soft tissues are closely related to their structure, biological conditions, and pathology. For years, physicians have used palpation as a crude elasticity measurement tool to diagnose diseases in the human body. Based on this simple concept, but using modern technology, several elasticity imaging schemes have been developed during the past two decades. In this paper, we present two elasticity imaging methods that use a low-frequency (Hz to kHz range) harmonic force to excite the tissue. The first method, called magnetic resonance elastography (MRE), uses a phase sensitive magnetic resonance technique to detect tissue motion. Excitation is usually performed with a mechanical actuator on the surface of the body, although other excitation methods are possible. In the second method, called vibro-acoustography, the radiation force from focused ultrasound is used for excitation in a limited region within the tissue. Tissue motion is detected by measuring the acoustic field emitted by the object in response to the vibration. The resulting images in both methods can be related to the dynamics of the object at the excitation frequency. The spatial resolution of MRE and vibro-acoustography images is in the millimeter and sub-millimeter ranges, respectively. Here, we present the theory and physical principles of MRE and vibro-acoustography and describe their performances. We also present results of experiments on various human tissues, including breast, brain, and vessels. Finally, we discuss potential clinical application of these two imaging methods.

KW - Elasticity

KW - Elastography

KW - Imaging

KW - Magnetic resonance imaging (MRI)

KW - Radiation force

KW - Ribro-acoustography

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=21344465423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21344465423&partnerID=8YFLogxK

U2 - 10.1109/JPROC.2003.817865

DO - 10.1109/JPROC.2003.817865

M3 - Article

AN - SCOPUS:21344465423

VL - 91

SP - 1503

EP - 1518

JO - Proceedings of the IEEE

JF - Proceedings of the IEEE

SN - 0018-9219

IS - 10

ER -