TY - JOUR
T1 - Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease
AU - Whitwell, Jennifer L.
AU - Graff-Radford, Jonathan
AU - Tosakulwong, Nirubol
AU - Weigand, Stephen D.
AU - Machulda, Mary M.
AU - Senjem, Matthew L.
AU - Spychalla, Anthony J.
AU - Vemuri, Prashanthi
AU - Jones, David T.
AU - Drubach, Daniel A.
AU - Knopman, David S.
AU - Boeve, Bradley F.
AU - Ertekin-Taner, Nilüfer
AU - Petersen, Ronald C.
AU - Lowe, Val J.
AU - Jack, Clifford R.
AU - Josephs, Keith A.
N1 - Publisher Copyright:
© 2018 the Alzheimer's Association
PY - 2018/8
Y1 - 2018/8
N2 - Introduction: Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods: We assessed subject-level regional correlations between tau on [ 18 F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [ 18 F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results: [ 18 F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [ 18 F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [ 18 F]AV-1451 uptake and cortical thickness. Discussion: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.
AB - Introduction: Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods: We assessed subject-level regional correlations between tau on [ 18 F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [ 18 F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results: [ 18 F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [ 18 F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [ 18 F]AV-1451 uptake and cortical thickness. Discussion: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.
KW - Alzheimer's disease
KW - Cortical thickness
KW - Logopenic aphasia
KW - Magnetic resonance imaging
KW - Positron emission tomography
KW - Posterior cortical atrophy
KW - Tau
KW - β amyloid
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U2 - 10.1016/j.jalz.2018.02.020
DO - 10.1016/j.jalz.2018.02.020
M3 - Article
C2 - 29605222
AN - SCOPUS:85046775618
SN - 1552-5260
VL - 14
SP - 1005
EP - 1014
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 8
ER -