Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease

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Abstract

Introduction: Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods: We assessed subject-level regional correlations between tau on [18F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [18F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results: [18F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [18F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [18F]AV-1451 uptake and cortical thickness. Discussion: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2018

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Amyloid
Positron-Emission Tomography
Atrophy
Alzheimer Disease
Neuroimaging
Fluorodeoxyglucose F18
Magnetic Resonance Imaging

Keywords

  • Alzheimer's disease
  • Cortical thickness
  • Logopenic aphasia
  • Magnetic resonance imaging
  • Positron emission tomography
  • Posterior cortical atrophy
  • Tau
  • β amyloid

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

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title = "Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease",
abstract = "Introduction: Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods: We assessed subject-level regional correlations between tau on [18F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [18F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results: [18F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [18F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [18F]AV-1451 uptake and cortical thickness. Discussion: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.",
keywords = "Alzheimer's disease, Cortical thickness, Logopenic aphasia, Magnetic resonance imaging, Positron emission tomography, Posterior cortical atrophy, Tau, β amyloid",
author = "Whitwell, {Jennifer Lynn} and Jonathan Graff-Radford and Nirubol Tosakulwong and Weigand, {Stephen D.} and Machulda, {Mary Margaret} and Senjem, {Matthew L.} and Spychalla, {Anthony J.} and Vemuri, {Prashanthi D} and Jones, {David T} and Daniel Drubach and Knopman, {David S} and Boeve, {Bradley F} and Nilufer Taner and Petersen, {Ronald Carl} and Val Lowe and Jack, {Clifford R Jr.} and Josephs, {Keith Anthony}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jalz.2018.02.020",
language = "English (US)",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
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T1 - Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease

AU - Whitwell, Jennifer Lynn

AU - Graff-Radford, Jonathan

AU - Tosakulwong, Nirubol

AU - Weigand, Stephen D.

AU - Machulda, Mary Margaret

AU - Senjem, Matthew L.

AU - Spychalla, Anthony J.

AU - Vemuri, Prashanthi D

AU - Jones, David T

AU - Drubach, Daniel

AU - Knopman, David S

AU - Boeve, Bradley F

AU - Taner, Nilufer

AU - Petersen, Ronald Carl

AU - Lowe, Val

AU - Jack, Clifford R Jr.

AU - Josephs, Keith Anthony

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods: We assessed subject-level regional correlations between tau on [18F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [18F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results: [18F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [18F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [18F]AV-1451 uptake and cortical thickness. Discussion: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.

AB - Introduction: Neuroimaging modalities can measure different aspects of the disease process in Alzheimer's disease, although the relationship between these modalities is unclear. Methods: We assessed subject-level regional correlations between tau on [18F]AV-1451 positron emission tomography (PET), β amyloid on Pittsburgh compound B PET, hypometabolism on [18F] fluorodeoxyglucose PET, and cortical thickness on magnetic resonance imaging in 96 participants with typical and atypical Alzheimer's disease presentations. We also assessed how correlations between modalities varied according to age, presenting syndrome, tau-PET severity, and asymmetry. Results: [18F]AV-1451 uptake showed the strongest regional correlation with hypometabolism. Correlations between [18F]AV-1451 uptake and both hypometabolism and cortical thickness were stronger in participants with greater cortical tau severity. In addition, age, tau asymmetry, and clinical diagnosis influenced the strength of the correlation between [18F]AV-1451 uptake and cortical thickness. Discussion: These findings support a close relationship between tau and hypometabolism in Alzheimer's disease but show that correlations between neuroimaging modalities vary across participants.

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KW - Cortical thickness

KW - Logopenic aphasia

KW - Magnetic resonance imaging

KW - Positron emission tomography

KW - Posterior cortical atrophy

KW - Tau

KW - β amyloid

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