Imaging correlates of posterior cortical atrophy

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 patients with PCA, 38 patients with typical AD, and 38 controls. Clinical data was assessed in all PCA patients. Single voxel 1H MRS located in the posterior cingulate was analyzed in a subset of patients with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Patients with PCA showed greater atrophy in the right visual association cortex than patients with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

Original languageEnglish (US)
Pages (from-to)1051-1061
Number of pages11
JournalNeurobiology of Aging
Volume28
Issue number7
DOIs
StatePublished - Jul 2007

Fingerprint

Atrophy
Alzheimer Disease
Magnetic Resonance Spectroscopy
Neurochemistry
Gyrus Cinguli
Visual Cortex
Temporal Lobe
Neuroglia
Hippocampus

Keywords

  • Alzheimer's disease
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Posterior cortical atrophy
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

@article{dfaae55726dc41dbac57415265bb494d,
title = "Imaging correlates of posterior cortical atrophy",
abstract = "The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 patients with PCA, 38 patients with typical AD, and 38 controls. Clinical data was assessed in all PCA patients. Single voxel 1H MRS located in the posterior cingulate was analyzed in a subset of patients with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Patients with PCA showed greater atrophy in the right visual association cortex than patients with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.",
keywords = "Alzheimer's disease, Magnetic resonance imaging, Magnetic resonance spectroscopy, Posterior cortical atrophy, Voxel-based morphometry",
author = "Whitwell, {Jennifer Lynn} and Jack, {Clifford R Jr.} and Kantarci, {Kejal M} and Weigand, {Stephen D.} and Boeve, {Bradley F} and Knopman, {David S} and Daniel Drubach and Tang-Wai, {David F.} and Petersen, {Ronald Carl} and Josephs, {Keith Anthony}",
year = "2007",
month = "7",
doi = "10.1016/j.neurobiolaging.2006.05.026",
language = "English (US)",
volume = "28",
pages = "1051--1061",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Imaging correlates of posterior cortical atrophy

AU - Whitwell, Jennifer Lynn

AU - Jack, Clifford R Jr.

AU - Kantarci, Kejal M

AU - Weigand, Stephen D.

AU - Boeve, Bradley F

AU - Knopman, David S

AU - Drubach, Daniel

AU - Tang-Wai, David F.

AU - Petersen, Ronald Carl

AU - Josephs, Keith Anthony

PY - 2007/7

Y1 - 2007/7

N2 - The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 patients with PCA, 38 patients with typical AD, and 38 controls. Clinical data was assessed in all PCA patients. Single voxel 1H MRS located in the posterior cingulate was analyzed in a subset of patients with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Patients with PCA showed greater atrophy in the right visual association cortex than patients with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

AB - The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in patients with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 patients with PCA, 38 patients with typical AD, and 38 controls. Clinical data was assessed in all PCA patients. Single voxel 1H MRS located in the posterior cingulate was analyzed in a subset of patients with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Patients with PCA showed greater atrophy in the right visual association cortex than patients with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and typical AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

KW - Alzheimer's disease

KW - Magnetic resonance imaging

KW - Magnetic resonance spectroscopy

KW - Posterior cortical atrophy

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=34247358231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247358231&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2006.05.026

DO - 10.1016/j.neurobiolaging.2006.05.026

M3 - Article

C2 - 16797786

AN - SCOPUS:34247358231

VL - 28

SP - 1051

EP - 1061

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 7

ER -