Imaging brain source extent from EEG/MEG by means of an iteratively reweighted edge sparsity minimization (IRES) strategy

Abbas Sohrabpour, Yunfeng Lu, Gregory Alan Worrell, Bin He

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Estimating extended brain sources using EEG/MEG source imaging techniques is challenging. EEG and MEG have excellent temporal resolution at millisecond scale but their spatial resolution is limited due to the volume conduction effect. We have exploited sparse signal processing techniques in this study to impose sparsity on the underlying source and its transformation in other domains (mathematical domains, like spatial gradient). Using an iterative reweighting strategy to penalize locations that are less likely to contain any source, it is shown that the proposed iteratively reweighted edge sparsity minimization (IRES) strategy can provide reasonable information regarding the location and extent of the underlying sources. This approach is unique in the sense that it estimates extended sources without the need of subjectively thresholding the solution. The performance of IRES was evaluated in a series of computer simulations. Different parameters such as source location and signal-to-noise ratio were varied and the estimated results were compared to the targets using metrics such as localization error (LE), area under curve (AUC) and overlap between the estimated and simulated sources. It is shown that IRES provides extended solutions which not only localize the source but also provide estimation for the source extent. The performance of IRES was further tested in epileptic patients undergoing intracranial EEG (iEEG) recording for pre-surgical evaluation. IRES was applied to scalp EEGs during interictal spikes, and results were compared with iEEG and surgical resection outcome in the patients. The pilot clinical study results are promising and demonstrate a good concordance between noninvasive IRES source estimation with iEEG and surgical resection outcomes in the same patients. The proposed algorithm, i.e. IRES, estimates extended source solutions from scalp electromagnetic signals which provide relatively accurate information about the location and extent of the underlying source.

Original languageEnglish (US)
Pages (from-to)27-42
Number of pages16
JournalNeuroImage
Volume142
DOIs
StatePublished - Nov 15 2016

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Neuroimaging
Electroencephalography
Scalp
Electromagnetic Phenomena
Signal-To-Noise Ratio
Computer Simulation
Area Under Curve
Brain
Electrocorticography
Clinical Studies

Keywords

  • Convex optimization
  • EEG
  • Extent
  • Inverse problem
  • Iterative reweighting
  • MEG
  • Source extent
  • Sparsity

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Imaging brain source extent from EEG/MEG by means of an iteratively reweighted edge sparsity minimization (IRES) strategy. / Sohrabpour, Abbas; Lu, Yunfeng; Worrell, Gregory Alan; He, Bin.

In: NeuroImage, Vol. 142, 15.11.2016, p. 27-42.

Research output: Contribution to journalArticle

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