Image reconstruction from limited angle projections collected by multisource interior x-ray imaging systems

Baodong Liu, Ge Wang, Erik L. Ritman, Guohua Cao, Jianping Lu, Otto Zhou, Li Zeng, Hengyong Yu

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A multisource x-ray interior imaging system with limited angle scanning is investigated to study the possibility of building an ultrafast micro-CT for dynamic small animal imaging, and two methods are employed to perform interior reconstruction from a limited number of projections collected by the multisource interior x-ray system. The first is total variation minimization with the steepest descent search (TVM-SD) and the second is total difference minimization with soft-threshold filtering (TDM-STF). Comprehensive numerical simulations and animal studies are performed to validate the associated reconstructed methods and demonstrate the feasibility and application of the proposed system configuration. The image reconstruction results show that both of the two reconstruction methods can significantly improve the image quality and the TDM-SFT is slightly superior to the TVM-SD. Finally, quantitative image analysis shows that it is possible to make an ultrafast micro-CT using a multisource interior x-ray system scheme combined with the state-of-the-art interior tomography.

Original languageEnglish (US)
Article number012
Pages (from-to)6337-6357
Number of pages21
JournalPhysics in medicine and biology
Volume56
Issue number19
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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