Ileal pouch-anal anastomosis: Does age at the time of surgery affect outcome?

Jennifer R. Chapman, David Larson, Bruce G. Wolff, Eric Dozois, Robert R. Cima, John H. Pemberton, B. S. Crownhart, Dirk R. Larson, David Rothenberger, R. Thirlby

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Hypothesis: Functional outcome and quality of life in older patients (> 55 years) undergoing ileal pouch-anal anastomosis (IPAA) for ulcerative colitis or familial adenomatous polyposis have been incompletely studied. Our aim was to update our understanding on how the age of the patient at the time of surgery influences functional outcome and quality of life after IPAA. Methods: From January 1, 1981, to December 31, 2000, two thousand two patients who underwent IPAA were studied. Patients were grouped by age at operation: 45 years or younger (n=1688), between 46 and 55 years (n=249), and older than 55 years (n=65). Mean age was 33.5 years. Postoperative complications, function, and quality of life were assessed with a questionnaire administered annually. Results: Follow-up for patients older than 55 years was a mean±SD of 8.1±4.8 years. Overall, follow-up was a mean of 10.1±5.7 years. The pouch failure rate for patients older than 55 years was 1.6% at 10 years. No statistically significant difference in pouch failure between age groups was observed. Overall, frequent daytime and nighttime incontinence, respectively, occurred in 5.6% and 13.3% of the patients at 10 years. Incontinence was more common in older patients (P=.002 at 3 years). Quality of life as assessed by social activities, work, travel, sexual activity, family relationships, and sports and recreation was not significantly different among age groups. Most patients felt that their condition had improved or that they had no restrictions after IPAA. Conclusions: Postoperative complications after surgery seem to be unrelated to age at the time of surgery. Although incontinence may occur more frequently in older patients, IPAA does not adversely affect quality of life in patients older than 55 years.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalArchives of Surgery
Volume140
Issue number6
DOIs
StatePublished - Jun 2005

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Colonic Pouches
Quality of Life
Age Groups
Recreation
Adenomatous Polyposis Coli
Family Relations
Ulcerative Colitis
Sexual Behavior
Sports

ASJC Scopus subject areas

  • Surgery

Cite this

Ileal pouch-anal anastomosis : Does age at the time of surgery affect outcome? / Chapman, Jennifer R.; Larson, David; Wolff, Bruce G.; Dozois, Eric; Cima, Robert R.; Pemberton, John H.; Crownhart, B. S.; Larson, Dirk R.; Rothenberger, David; Thirlby, R.

In: Archives of Surgery, Vol. 140, No. 6, 06.2005, p. 534-540.

Research output: Contribution to journalArticle

Chapman, JR, Larson, D, Wolff, BG, Dozois, E, Cima, RR, Pemberton, JH, Crownhart, BS, Larson, DR, Rothenberger, D & Thirlby, R 2005, 'Ileal pouch-anal anastomosis: Does age at the time of surgery affect outcome?', Archives of Surgery, vol. 140, no. 6, pp. 534-540. https://doi.org/10.1001/archsurg.140.6.534
Chapman, Jennifer R. ; Larson, David ; Wolff, Bruce G. ; Dozois, Eric ; Cima, Robert R. ; Pemberton, John H. ; Crownhart, B. S. ; Larson, Dirk R. ; Rothenberger, David ; Thirlby, R. / Ileal pouch-anal anastomosis : Does age at the time of surgery affect outcome?. In: Archives of Surgery. 2005 ; Vol. 140, No. 6. pp. 534-540.
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abstract = "Hypothesis: Functional outcome and quality of life in older patients (> 55 years) undergoing ileal pouch-anal anastomosis (IPAA) for ulcerative colitis or familial adenomatous polyposis have been incompletely studied. Our aim was to update our understanding on how the age of the patient at the time of surgery influences functional outcome and quality of life after IPAA. Methods: From January 1, 1981, to December 31, 2000, two thousand two patients who underwent IPAA were studied. Patients were grouped by age at operation: 45 years or younger (n=1688), between 46 and 55 years (n=249), and older than 55 years (n=65). Mean age was 33.5 years. Postoperative complications, function, and quality of life were assessed with a questionnaire administered annually. Results: Follow-up for patients older than 55 years was a mean±SD of 8.1±4.8 years. Overall, follow-up was a mean of 10.1±5.7 years. The pouch failure rate for patients older than 55 years was 1.6{\%} at 10 years. No statistically significant difference in pouch failure between age groups was observed. Overall, frequent daytime and nighttime incontinence, respectively, occurred in 5.6{\%} and 13.3{\%} of the patients at 10 years. Incontinence was more common in older patients (P=.002 at 3 years). Quality of life as assessed by social activities, work, travel, sexual activity, family relationships, and sports and recreation was not significantly different among age groups. Most patients felt that their condition had improved or that they had no restrictions after IPAA. Conclusions: Postoperative complications after surgery seem to be unrelated to age at the time of surgery. Although incontinence may occur more frequently in older patients, IPAA does not adversely affect quality of life in patients older than 55 years.",
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T1 - Ileal pouch-anal anastomosis

T2 - Does age at the time of surgery affect outcome?

AU - Chapman, Jennifer R.

AU - Larson, David

AU - Wolff, Bruce G.

AU - Dozois, Eric

AU - Cima, Robert R.

AU - Pemberton, John H.

AU - Crownhart, B. S.

AU - Larson, Dirk R.

AU - Rothenberger, David

AU - Thirlby, R.

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N2 - Hypothesis: Functional outcome and quality of life in older patients (> 55 years) undergoing ileal pouch-anal anastomosis (IPAA) for ulcerative colitis or familial adenomatous polyposis have been incompletely studied. Our aim was to update our understanding on how the age of the patient at the time of surgery influences functional outcome and quality of life after IPAA. Methods: From January 1, 1981, to December 31, 2000, two thousand two patients who underwent IPAA were studied. Patients were grouped by age at operation: 45 years or younger (n=1688), between 46 and 55 years (n=249), and older than 55 years (n=65). Mean age was 33.5 years. Postoperative complications, function, and quality of life were assessed with a questionnaire administered annually. Results: Follow-up for patients older than 55 years was a mean±SD of 8.1±4.8 years. Overall, follow-up was a mean of 10.1±5.7 years. The pouch failure rate for patients older than 55 years was 1.6% at 10 years. No statistically significant difference in pouch failure between age groups was observed. Overall, frequent daytime and nighttime incontinence, respectively, occurred in 5.6% and 13.3% of the patients at 10 years. Incontinence was more common in older patients (P=.002 at 3 years). Quality of life as assessed by social activities, work, travel, sexual activity, family relationships, and sports and recreation was not significantly different among age groups. Most patients felt that their condition had improved or that they had no restrictions after IPAA. Conclusions: Postoperative complications after surgery seem to be unrelated to age at the time of surgery. Although incontinence may occur more frequently in older patients, IPAA does not adversely affect quality of life in patients older than 55 years.

AB - Hypothesis: Functional outcome and quality of life in older patients (> 55 years) undergoing ileal pouch-anal anastomosis (IPAA) for ulcerative colitis or familial adenomatous polyposis have been incompletely studied. Our aim was to update our understanding on how the age of the patient at the time of surgery influences functional outcome and quality of life after IPAA. Methods: From January 1, 1981, to December 31, 2000, two thousand two patients who underwent IPAA were studied. Patients were grouped by age at operation: 45 years or younger (n=1688), between 46 and 55 years (n=249), and older than 55 years (n=65). Mean age was 33.5 years. Postoperative complications, function, and quality of life were assessed with a questionnaire administered annually. Results: Follow-up for patients older than 55 years was a mean±SD of 8.1±4.8 years. Overall, follow-up was a mean of 10.1±5.7 years. The pouch failure rate for patients older than 55 years was 1.6% at 10 years. No statistically significant difference in pouch failure between age groups was observed. Overall, frequent daytime and nighttime incontinence, respectively, occurred in 5.6% and 13.3% of the patients at 10 years. Incontinence was more common in older patients (P=.002 at 3 years). Quality of life as assessed by social activities, work, travel, sexual activity, family relationships, and sports and recreation was not significantly different among age groups. Most patients felt that their condition had improved or that they had no restrictions after IPAA. Conclusions: Postoperative complications after surgery seem to be unrelated to age at the time of surgery. Although incontinence may occur more frequently in older patients, IPAA does not adversely affect quality of life in patients older than 55 years.

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