ILC2s and fungal allergy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Abstract Innate lymphoid cells (ILCs) have emerged recently as an important component of the immune system and the cell type that regulates mucosal immune responses and tissue homeostasis. Group 2 ILCs (ILC2s), a subset of ILCs, reside in various tissues and are characterized by their capacity to produce type 2 cytokines and tissue growth factors. These ILC2s play an important role in allergic immune responses by linking signals in the atmospheric environment to the immune system. Fungi are one of the major allergens associated with human asthma, and animal and in vitro models using the fungal allergens have provided significant information toward our understanding of the mechanisms of allergic disease. In mouse models of fungus-induced allergic airway inflammation, IL-33, IL-25, and TSLP are released by airway epithelial cells. Lung ILC2s that respond to these cytokines quickly produce a large quantity of type 2 cytokines, resulting in airway eosinophilia, mucus production, and airway hyperreactivity even in the absence of adaptive immune cells. Evidence also suggests that ILC2s interact with conventional immune cells, such as CD4<sup>+</sup> T cells, and facilitate development of adaptive immune response and persistent airway inflammation. ILC2s are also present in respiratory mucosa in humans. Further investigations into the biology of ILC2s and their roles in the pathophysiology of allergic diseases will provide major conceptual advances in the field and may provide useful information toward development of new therapeutic strategies for patients.

Original languageEnglish (US)
Article number66
Pages (from-to)219-226
Number of pages8
JournalAllergology International
Volume64
Issue number3
DOIs
StatePublished - Jul 1 2015

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Hypersensitivity
Cytokines
Allergens
Immune System
Fungi
Lymphocytes
Inflammation
Respiratory Mucosa
Mucosal Immunity
Eosinophilia
Thromboplastin
Adaptive Immunity
Mucus
Intercellular Signaling Peptides and Proteins
Homeostasis
Asthma
Epithelial Cells
T-Lymphocytes
Lung
Therapeutics

Keywords

  • Allergy
  • Asthma
  • Cytokines
  • Fungi
  • Innate lymphoid cells

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

ILC2s and fungal allergy. / Kita, Hirohito.

In: Allergology International, Vol. 64, No. 3, 66, 01.07.2015, p. 219-226.

Research output: Contribution to journalArticle

Kita, Hirohito. / ILC2s and fungal allergy. In: Allergology International. 2015 ; Vol. 64, No. 3. pp. 219-226.
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