Abstract
This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 897-903 |
| Number of pages | 7 |
| Journal | Leukemia and Lymphoma |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2003 |
Keywords
- Apoptosis
- B-CLL
- IL-4
- IL-4R
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research