IL-4 biology

Impact on normal and leukemic CLL B cells

Neil Elliot Kay, Brian T. Pittner

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.

Original languageEnglish (US)
Pages (from-to)897-903
Number of pages7
JournalLeukemia and Lymphoma
Volume44
Issue number6
DOIs
StatePublished - Jun 1 2003

Fingerprint

Interleukin-4
B-Lymphocytes
Cytokine Receptors
Cell Differentiation
Cell Proliferation
Apoptosis
Cytokines
T-Lymphocytes
Proteins
Therapeutics

Keywords

  • Apoptosis
  • B-CLL
  • IL-4
  • IL-4R

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

IL-4 biology : Impact on normal and leukemic CLL B cells. / Kay, Neil Elliot; Pittner, Brian T.

In: Leukemia and Lymphoma, Vol. 44, No. 6, 01.06.2003, p. 897-903.

Research output: Contribution to journalArticle

Kay, Neil Elliot ; Pittner, Brian T. / IL-4 biology : Impact on normal and leukemic CLL B cells. In: Leukemia and Lymphoma. 2003 ; Vol. 44, No. 6. pp. 897-903.
@article{326cea5c77de4f69a5594ea38f7c2231,
title = "IL-4 biology: Impact on normal and leukemic CLL B cells",
abstract = "This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.",
keywords = "Apoptosis, B-CLL, IL-4, IL-4R",
author = "Kay, {Neil Elliot} and Pittner, {Brian T.}",
year = "2003",
month = "6",
day = "1",
doi = "10.1080/1042819031000068007",
language = "English (US)",
volume = "44",
pages = "897--903",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - IL-4 biology

T2 - Impact on normal and leukemic CLL B cells

AU - Kay, Neil Elliot

AU - Pittner, Brian T.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.

AB - This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.

KW - Apoptosis

KW - B-CLL

KW - IL-4

KW - IL-4R

UR - http://www.scopus.com/inward/record.url?scp=0037409786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037409786&partnerID=8YFLogxK

U2 - 10.1080/1042819031000068007

DO - 10.1080/1042819031000068007

M3 - Article

VL - 44

SP - 897

EP - 903

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 6

ER -