Abstract
Interleukin (IL)-33 is a key cytokine involved in type 2 immunity and allergic airway diseases. Abundantly expressed in lung epithelial cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs. In innate immunity, IL-33 and group 2 innate lymphoid cells (ILC2s) provide an essential axis for rapid immune responses and tissue homeostasis. In adaptive immunity, IL-33 interacts with dendritic cells, Th2 cells, follicular T cells, and regulatory T cells, where IL-33 influences the development of chronic airway inflammation and tissue remodeling. The clinical findings that both the IL-33 and ILC2 levels are elevated in patients with allergic airway diseases suggest that IL-33 plays an important role in the pathogenesis of these diseases. IL-33 and ILC2 may also serve as biomarkers for disease classification and to monitor the progression of diseases. In this article, we reviewed the current knowledge of the biology of IL-33 and discussed the roles of the IL-33 in regulating airway immune responses and allergic airway diseases.
Original language | English (US) |
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Pages (from-to) | 173-184 |
Number of pages | 12 |
Journal | Immunological Reviews |
Volume | 278 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2017 |
Keywords
- IL-33
- ILC2s
- Th2 cells
- asthma
- rhinosinusitis
- type 2 immunity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology