IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21

Adrianna Moroz, Cheryl Eppolito, Qingsheng Li, Jianming Tao, Christopher H. Clegg, Protul A. Shrikant

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Cytokines that use the common receptor γ-chain for regulating CD8+ T cell responses to Ag include IL-2, IL-15, and the recently identified IL-21. The ability of these cytokines to regulate antitumor activity in mice has generated considerable interest in understanding their mode of action. In this study we compare the abilities of IL-2, IL-15, and IL-21 to stimulate immunity against tumors in a syngeneic thymoma model. Durable cures were only achieved in IL-21-treated mice. By monitoring both endogenous and adoptively transferred tumor Ag-specific CD8+ T cells, it was determined that IL-21 activities overlap with those of IL-2 and IL-15. Similar to IL-2, IL-21 enhanced Ag activation and clonal expansion. However, unlike IL-2 treatment, which induces activation-induced cell death, IL-21 sustained CD8+ T cell numbers long term as a result of increased survival, an effect often attributed to IL-15. These findings indicate that the mechanisms used by IL-21 to promote CD8+ T cell responses offer unique opportunities for its use in malignant diseases and infections.

Original languageEnglish (US)
Pages (from-to)900-909
Number of pages10
JournalJournal of Immunology
Volume173
Issue number2
StatePublished - Jul 15 2004
Externally publishedYes

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Interleukin-15
Interleukin-2
Immunity
T-Lymphocytes
Neoplasms
Cytokines
Thymoma
interleukin-21
Cell Death
Cell Count
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Moroz, A., Eppolito, C., Li, Q., Tao, J., Clegg, C. H., & Shrikant, P. A. (2004). IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21. Journal of Immunology, 173(2), 900-909.

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity : Comparative evaluation of IL-2, IL-15, and IL-21. / Moroz, Adrianna; Eppolito, Cheryl; Li, Qingsheng; Tao, Jianming; Clegg, Christopher H.; Shrikant, Protul A.

In: Journal of Immunology, Vol. 173, No. 2, 15.07.2004, p. 900-909.

Research output: Contribution to journalArticle

Moroz, A, Eppolito, C, Li, Q, Tao, J, Clegg, CH & Shrikant, PA 2004, 'IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: Comparative evaluation of IL-2, IL-15, and IL-21', Journal of Immunology, vol. 173, no. 2, pp. 900-909.
Moroz, Adrianna ; Eppolito, Cheryl ; Li, Qingsheng ; Tao, Jianming ; Clegg, Christopher H. ; Shrikant, Protul A. / IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity : Comparative evaluation of IL-2, IL-15, and IL-21. In: Journal of Immunology. 2004 ; Vol. 173, No. 2. pp. 900-909.
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