TY - JOUR
T1 - IL-10 Inhibits FcεRI Expression in Mouse Mast Cells
AU - Gillespie, Sheila R.
AU - DeMartino, Randall R.
AU - Zhu, Jingfang
AU - Chong, Hey Jin
AU - Ramirez, Carlos
AU - Shelburne, Christopher P.
AU - Bouton, L. Andrew
AU - Bailey, Daniel P.
AU - Gharse, Anita
AU - Mirmonsef, Paria
AU - Odom, Sandra
AU - Gomez, Gregorio
AU - Rivera, Juan
AU - Fischer-Stenger, Krista
AU - Ryan, John J.
PY - 2004/3/1
Y1 - 2004/3/1
N2 - FcεRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown that the Th2 cytokine IL-4 inhibits FcεRI expression and function. In the current study we show that the Th2 cytokine IL-10 has similar regulatory properties, and that it augments the inhibitory effects of IL-4. FcεRI down-regulation was functionally significant, as it diminished inflammatory cytokine production and IgE-mediated FcεRI up-regulation. IL-10 and IL-4 reduced FcεRI β protein expression without altering the α or γ subunits. The ability of IL-4 and IL-10 to alter FcεRI expression by targeting the β-chain, a critical receptor subunit known to modulate receptor expression and signaling, suggests the presence of a Th2 cytokine-mediated homeostatic network that could serve to both initiate and limit mast cell effector function.
AB - FcεRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown that the Th2 cytokine IL-4 inhibits FcεRI expression and function. In the current study we show that the Th2 cytokine IL-10 has similar regulatory properties, and that it augments the inhibitory effects of IL-4. FcεRI down-regulation was functionally significant, as it diminished inflammatory cytokine production and IgE-mediated FcεRI up-regulation. IL-10 and IL-4 reduced FcεRI β protein expression without altering the α or γ subunits. The ability of IL-4 and IL-10 to alter FcεRI expression by targeting the β-chain, a critical receptor subunit known to modulate receptor expression and signaling, suggests the presence of a Th2 cytokine-mediated homeostatic network that could serve to both initiate and limit mast cell effector function.
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U2 - 10.4049/jimmunol.172.5.3181
DO - 10.4049/jimmunol.172.5.3181
M3 - Article
C2 - 14978125
AN - SCOPUS:10744224523
SN - 0022-1767
VL - 172
SP - 3181
EP - 3188
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -