Igm myeloma with plasma cell leukemia: Case report and literature review

Saurabh Chhabra, Sandeep Jain, Amanda Fowler, Valeriy Sedov, Amarendra K. Neppalli, Cynthia A. Schandl, John Lazarchick

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

IgM multiple myeloma (MM) is a rare entity representing approximately 0.5% of all MM. It should be distinguished from malignant neoplasms of B cells with plasmacytic differentiation such as Waldenstrom macroglobulinemia (WM) and marginal zone lymphoma with plasmacytic differentiation. Plasma cell leukemia (PCL) is a rare and aggressive variant ofMMcharacterized by the presence of circulating plasma cells. We present a case report of a patient who presented with IgM MM in primary PCL phase with high-risk cytogenetics. To our knowledge, this is the first reported case of IgM MM with primarily leukemic presentation in the era of novel drugs. We demonstrate that it is important to distinguish IgM MM fromWM and review the data from clinical trials that was used to devise a treatment strategy for this high-risk patient. This case adds to the understanding of the diagnosis and management of IgM MM in leukemic phase.

Original languageEnglish (US)
Pages (from-to)611-619
Number of pages9
JournalAnnals of Clinical and Laboratory Science
Volume47
Issue number5
StatePublished - Sep 1 2017

Keywords

  • Deletion 17p
  • Deletion TP53
  • High-risk
  • IgM multiple myeloma
  • Plasma cell leukemia

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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  • Cite this

    Chhabra, S., Jain, S., Fowler, A., Sedov, V., Neppalli, A. K., Schandl, C. A., & Lazarchick, J. (2017). Igm myeloma with plasma cell leukemia: Case report and literature review. Annals of Clinical and Laboratory Science, 47(5), 611-619.