IgH translocations in multiple myeloma: A nearly universal event that rarely involves c-myc

P. L. Bergsagel, E. Nardini, L. Brents, M. Chesi, W. M. Kuehl

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Dysregulation of c-myc by translocation to the switch regions of the IgH locus occurs in most murine plasmacytomas. Translocations involving 14q32 have been reported in 20-40% of abnormal karyotypes from human multiple myeloma (MM), and involve a variety of loci. Using cytogenetics, FISH and a Southern blot assay, we analyzed 21 MM cell lines and one plasma cell leukemia and identified evidence of a 14q32 translocation in 20/22 samples. The partner loci involved are 11q13 in 6 (associated with cyclin D1 expression), 4p16 in 6 (associated with FGFR3 expression), unidentified in 3 and 1p13, 6, gq24, 12q24, 16q23, and 21q22 once each. We conclude that conventional karyotypes underestimate the frequency of 14q32 translocations in MM, where they appear to be a nearly universal event. The translocations most frequently involve IgH switch regions, and include two recurrent partner loci (11q13 and 4p16) and a promiscuous array of other partner loci. Although c-myc appears to be cis-dysregulated frequently in MM, it is only rarely translocated to the IgH locus.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalCurrent topics in microbiology and immunology
Volume224
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'IgH translocations in multiple myeloma: A nearly universal event that rarely involves c-myc'. Together they form a unique fingerprint.

Cite this