IgG4-related kidney disease

Lynn D. Cornell

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

IgG4-related kidney disease is a term that refers to any form of renal involvement by IgG4-related disease (IgG4-RD), a recently recognized systemic immune-mediated disease. The most common renal manifestation is IgG4-related tubulointerstitial nephritis (IgG4-TIN), which presents as acute or chronic renal insufficiency, renal mass lesions, or both. On biopsy, IgG4-TIN shows a plasma cell-rich interstitial inflammatory infiltrate with increased IgG4+ plasma cells, along with expansile interstitial fibrosis; tubular basement membrane immune complex deposits are common. IgG4-TIN usually shows a brisk response to immunosuppressive therapy. Glomeruli may be affected by IgG4-RD, usually in the form of membranous glomerulonephritis. Other patterns of glomerular disease include IgA nephropathy, membranoproliferative glomerulonephritis, and endocapillary or mesangioproliferative immune complex glomerulonephritis. IgG4-related plasma cell arteritis has also been observed in the kidney. This review describes the histopathologic and immunophenotypic patterns of renal involvement by IgG4-RD, with associated clinical, radiographic, and serologic features.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalSeminars in Diagnostic Pathology
Volume29
Issue number4
DOIs
StatePublished - Nov 2012

Keywords

  • Glomerulonephritis;
  • IgG4-related disease;
  • Immune complex;
  • Interstitial nephritis;
  • Membranous
  • Nephropathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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