IFNG polymorphisms are associated with gender differences in susceptibiligy to multiple sclerosis

Orhun H Kantarci, A. Goris, D. D. Hebrink, S. Heggarty, S. Cunningham, I. Alloza, E. J. Atkinson, Mariza De Andrade, C. T. McMurray, C. A. Graham, S. A. Hawkins, A. Billiau, B. Dubois, Brian G Weinshenker, K. Vandenbroeck

Research output: Contribution to journalArticle

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Abstract

Interferon-gamma (IFNγ) treatment is deleterious in multiple sclerosis (MS). MS occurs twice as frequently in women as in men. IFNγ expression varies by gender. We studied a population-based sample of US MS patients and ethnicity-matched controls and independent Northern Irish and Belgian hospital-based patients and controls for association with MS, stratified by gender, of an intron 1 microsatellite [I1(761)*CAn], a single nucleotide polymorphism 3′ of IFNG [3′ (325)* G → A] and three flanking microsatellite markers spanning a 118kb region around IFNG. Men carriers of the 3′ (325)* A allele have increased susceptibility to MS compared to noncarriers in the USA (P=0.044; OR: 2.58, 95% CI: 0.97-8.08) and Northern Ireland (P=0.019; OR: 2.37, 95% CI: 1.10-5.13). There is a nonsignificant trend in the same direction in Belgian men (P=0.299, OR: 1.50, 95% CI: 0.71-3.26). Men carriers of I1(761)* CA13, which is in strong linkage disequilibrium with the 3′ (325)* A, have increased susceptibility (P=0.050; OR: 2.22, 95% CI: 0.98-5.40), while men carriers of I1(761)* CA12 have decreased susceptibility (P=0.022; OR: 0.46, 95% CI: 0.23-0.90) to MS in the USA. Similar associations were reported in Sardinia between the I1(761)* CA12 allele and reduced risk of MS in men. Flanking markers were not associated with MS susceptibility. Polymorphisms of IFNG may contribute to differences in susceptibility to MS between men and women.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalGenes and Immunity
Volume6
Issue number2
DOIs
StatePublished - Mar 2005

Fingerprint

Multiple Sclerosis
Microsatellite Repeats
Interferon-gamma
Alleles
Northern Ireland
Linkage Disequilibrium
Introns
Italy
Single Nucleotide Polymorphism
Population

Keywords

  • Association
  • Gender
  • Interferon gamma (IFNG)
  • Multiple sclerosis
  • Polymorphisms

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Kantarci, O. H., Goris, A., Hebrink, D. D., Heggarty, S., Cunningham, S., Alloza, I., ... Vandenbroeck, K. (2005). IFNG polymorphisms are associated with gender differences in susceptibiligy to multiple sclerosis. Genes and Immunity, 6(2), 153-161. https://doi.org/10.1038/sj.gene.6364164

IFNG polymorphisms are associated with gender differences in susceptibiligy to multiple sclerosis. / Kantarci, Orhun H; Goris, A.; Hebrink, D. D.; Heggarty, S.; Cunningham, S.; Alloza, I.; Atkinson, E. J.; De Andrade, Mariza; McMurray, C. T.; Graham, C. A.; Hawkins, S. A.; Billiau, A.; Dubois, B.; Weinshenker, Brian G; Vandenbroeck, K.

In: Genes and Immunity, Vol. 6, No. 2, 03.2005, p. 153-161.

Research output: Contribution to journalArticle

Kantarci, OH, Goris, A, Hebrink, DD, Heggarty, S, Cunningham, S, Alloza, I, Atkinson, EJ, De Andrade, M, McMurray, CT, Graham, CA, Hawkins, SA, Billiau, A, Dubois, B, Weinshenker, BG & Vandenbroeck, K 2005, 'IFNG polymorphisms are associated with gender differences in susceptibiligy to multiple sclerosis', Genes and Immunity, vol. 6, no. 2, pp. 153-161. https://doi.org/10.1038/sj.gene.6364164
Kantarci, Orhun H ; Goris, A. ; Hebrink, D. D. ; Heggarty, S. ; Cunningham, S. ; Alloza, I. ; Atkinson, E. J. ; De Andrade, Mariza ; McMurray, C. T. ; Graham, C. A. ; Hawkins, S. A. ; Billiau, A. ; Dubois, B. ; Weinshenker, Brian G ; Vandenbroeck, K. / IFNG polymorphisms are associated with gender differences in susceptibiligy to multiple sclerosis. In: Genes and Immunity. 2005 ; Vol. 6, No. 2. pp. 153-161.
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abstract = "Interferon-gamma (IFNγ) treatment is deleterious in multiple sclerosis (MS). MS occurs twice as frequently in women as in men. IFNγ expression varies by gender. We studied a population-based sample of US MS patients and ethnicity-matched controls and independent Northern Irish and Belgian hospital-based patients and controls for association with MS, stratified by gender, of an intron 1 microsatellite [I1(761)*CAn], a single nucleotide polymorphism 3′ of IFNG [3′ (325)* G → A] and three flanking microsatellite markers spanning a 118kb region around IFNG. Men carriers of the 3′ (325)* A allele have increased susceptibility to MS compared to noncarriers in the USA (P=0.044; OR: 2.58, 95{\%} CI: 0.97-8.08) and Northern Ireland (P=0.019; OR: 2.37, 95{\%} CI: 1.10-5.13). There is a nonsignificant trend in the same direction in Belgian men (P=0.299, OR: 1.50, 95{\%} CI: 0.71-3.26). Men carriers of I1(761)* CA13, which is in strong linkage disequilibrium with the 3′ (325)* A, have increased susceptibility (P=0.050; OR: 2.22, 95{\%} CI: 0.98-5.40), while men carriers of I1(761)* CA12 have decreased susceptibility (P=0.022; OR: 0.46, 95{\%} CI: 0.23-0.90) to MS in the USA. Similar associations were reported in Sardinia between the I1(761)* CA12 allele and reduced risk of MS in men. Flanking markers were not associated with MS susceptibility. Polymorphisms of IFNG may contribute to differences in susceptibility to MS between men and women.",
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AU - Kantarci, Orhun H

AU - Goris, A.

AU - Hebrink, D. D.

AU - Heggarty, S.

AU - Cunningham, S.

AU - Alloza, I.

AU - Atkinson, E. J.

AU - De Andrade, Mariza

AU - McMurray, C. T.

AU - Graham, C. A.

AU - Hawkins, S. A.

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