TY - JOUR
T1 - IFN- γ Priming Effects on the Maintenance of Effector Memory CD4+ T Cells and on Phagocyte Function
T2 - Evidences from Infectious Diseases
AU - Da Silva, Henrique Borges
AU - Fonseca, Raíssa
AU - Alvarez, José M.
AU - Lima, Maria Regina D.Império
N1 - Publisher Copyright:
© 2015 Henrique Borges da Silva et al.
PY - 2015
Y1 - 2015
N2 - Although it has been established that effector memory CD4+ T cells play an important role in the protective immunity against chronic infections, little is known about the exact mechanisms responsible for their functioning and maintenance, as well as their effects on innate immune cells. Here we review recent data on the role of IFN-γ priming as a mechanism affecting both innate immune cells and effector memory CD4+ T cells. Suboptimal concentrations of IFN-γ are seemingly crucial for the optimization of innate immune cell functions (including phagocytosis and destruction of reminiscent pathogens), as well as for the survival and functioning of effector memory CD4+ T cells. Thus, IFN-γ priming can thus be considered an important bridge between innate and adaptive immunity.
AB - Although it has been established that effector memory CD4+ T cells play an important role in the protective immunity against chronic infections, little is known about the exact mechanisms responsible for their functioning and maintenance, as well as their effects on innate immune cells. Here we review recent data on the role of IFN-γ priming as a mechanism affecting both innate immune cells and effector memory CD4+ T cells. Suboptimal concentrations of IFN-γ are seemingly crucial for the optimization of innate immune cell functions (including phagocytosis and destruction of reminiscent pathogens), as well as for the survival and functioning of effector memory CD4+ T cells. Thus, IFN-γ priming can thus be considered an important bridge between innate and adaptive immunity.
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U2 - 10.1155/2015/202816
DO - 10.1155/2015/202816
M3 - Review article
C2 - 26509177
AN - SCOPUS:85052086590
SN - 2314-8861
VL - 2015
JO - Journal of Immunology Research
JF - Journal of Immunology Research
M1 - 202816
ER -