Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst

Michael D. Whitaker, Robert G. McArthur, Bernard Corenblum, Morris Davidman, Robert H. Haslam

Research output: Contribution to journalArticle

Abstract

A 15 year old girl presented with excessive thirst and hypertension ( 170 110 mm Hg). Biochemical investigations revealed serum sodium 118 meq/liter, serum osmolality 238 mosmol/liter, urine sodium 90 meq/liter, urine osmolality 700 mosmol/liter, persistently elevated serum antidiuretic hormone (ADH) levels (5.8 to 11.9 pg/ml) and no obvious cause for the hypertension. The hypertension is, at least in part, volume-related, diminishing with fluid restriction. Features of gross water intoxication (e.g., confusion, coma) have not occurred. The etiology of the inappropriate secretion of ADH is not obvious but is not thought to be due to "resetting of osmoreceptors" as evidenced by failure to maximally dilute urine following a water load test and persistently elevated serum ADH levels. A similar patient described by Epstein and associates in 1962 is presently well with persistent features of inappropriate secretion of ADH.

Original languageEnglish (US)
Pages (from-to)511-515
Number of pages5
JournalThe American journal of medicine
Volume67
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

Fingerprint

Inappropriate ADH Syndrome
Thirst
Hypertension
Urine
Serum
Vasopressins
Osmolar Concentration
Sodium
Water Intoxication
Confusion
Coma
Water

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst. / Whitaker, Michael D.; McArthur, Robert G.; Corenblum, Bernard; Davidman, Morris; Haslam, Robert H.

In: The American journal of medicine, Vol. 67, No. 3, 1979, p. 511-515.

Research output: Contribution to journalArticle

Whitaker, Michael D. ; McArthur, Robert G. ; Corenblum, Bernard ; Davidman, Morris ; Haslam, Robert H. / Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst. In: The American journal of medicine. 1979 ; Vol. 67, No. 3. pp. 511-515.
@article{c6ab36f69b60491fa4927061691f0d46,
title = "Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst",
abstract = "A 15 year old girl presented with excessive thirst and hypertension ( 170 110 mm Hg). Biochemical investigations revealed serum sodium 118 meq/liter, serum osmolality 238 mosmol/liter, urine sodium 90 meq/liter, urine osmolality 700 mosmol/liter, persistently elevated serum antidiuretic hormone (ADH) levels (5.8 to 11.9 pg/ml) and no obvious cause for the hypertension. The hypertension is, at least in part, volume-related, diminishing with fluid restriction. Features of gross water intoxication (e.g., confusion, coma) have not occurred. The etiology of the inappropriate secretion of ADH is not obvious but is not thought to be due to {"}resetting of osmoreceptors{"} as evidenced by failure to maximally dilute urine following a water load test and persistently elevated serum ADH levels. A similar patient described by Epstein and associates in 1962 is presently well with persistent features of inappropriate secretion of ADH.",
author = "Whitaker, {Michael D.} and McArthur, {Robert G.} and Bernard Corenblum and Morris Davidman and Haslam, {Robert H.}",
year = "1979",
doi = "10.1016/0002-9343(79)90802-7",
language = "English (US)",
volume = "67",
pages = "511--515",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Idiopathic, sustained, inappropriate secretion of ADH with associated hypertension and thirst

AU - Whitaker, Michael D.

AU - McArthur, Robert G.

AU - Corenblum, Bernard

AU - Davidman, Morris

AU - Haslam, Robert H.

PY - 1979

Y1 - 1979

N2 - A 15 year old girl presented with excessive thirst and hypertension ( 170 110 mm Hg). Biochemical investigations revealed serum sodium 118 meq/liter, serum osmolality 238 mosmol/liter, urine sodium 90 meq/liter, urine osmolality 700 mosmol/liter, persistently elevated serum antidiuretic hormone (ADH) levels (5.8 to 11.9 pg/ml) and no obvious cause for the hypertension. The hypertension is, at least in part, volume-related, diminishing with fluid restriction. Features of gross water intoxication (e.g., confusion, coma) have not occurred. The etiology of the inappropriate secretion of ADH is not obvious but is not thought to be due to "resetting of osmoreceptors" as evidenced by failure to maximally dilute urine following a water load test and persistently elevated serum ADH levels. A similar patient described by Epstein and associates in 1962 is presently well with persistent features of inappropriate secretion of ADH.

AB - A 15 year old girl presented with excessive thirst and hypertension ( 170 110 mm Hg). Biochemical investigations revealed serum sodium 118 meq/liter, serum osmolality 238 mosmol/liter, urine sodium 90 meq/liter, urine osmolality 700 mosmol/liter, persistently elevated serum antidiuretic hormone (ADH) levels (5.8 to 11.9 pg/ml) and no obvious cause for the hypertension. The hypertension is, at least in part, volume-related, diminishing with fluid restriction. Features of gross water intoxication (e.g., confusion, coma) have not occurred. The etiology of the inappropriate secretion of ADH is not obvious but is not thought to be due to "resetting of osmoreceptors" as evidenced by failure to maximally dilute urine following a water load test and persistently elevated serum ADH levels. A similar patient described by Epstein and associates in 1962 is presently well with persistent features of inappropriate secretion of ADH.

UR - http://www.scopus.com/inward/record.url?scp=0018690693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018690693&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(79)90802-7

DO - 10.1016/0002-9343(79)90802-7

M3 - Article

AN - SCOPUS:0018690693

VL - 67

SP - 511

EP - 515

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 3

ER -