Idiopathic rapid-eye-movement sleep disorder: Associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset

Paul T. Teman, Maja Tippmann-Peikert, Michael H. Silber, Nancy L. Slocumb, Robert R Auger

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: A retrospective, case-control chart review was performed to examine the relationship between the age of onset of idiopathic RBD and secondary associations. Methods: Forty-eight idiopathic RBD patients were divided into early-onset and late-onset groups, compared to each other, and to their respective non-RBD controls. Results: There were more females in the early-onset group as compared to their older counterparts (45% vs. 11%, p = 0.007). Early-onset patients also had significantly more past and present psychiatric diagnoses [85% (both categories) vs. 46% and 36%, respectively, p < 0.01 for both comparisons] and antidepressant use (80% vs. 46%, p = 0.02) than the late-onset group. In comparison to non-RBD controls, early-onset patients again exhibited more psychiatric diagnoses (odds ratio = 17.0 [3.5-83.4], equivalent for past and present diagnoses) and antidepressant use (odds ratio = 12.0 [2.7-53.3]). Late-onset patients also had a higher frequency of past (odds ratio = 7.2 [1.8-29.6]) and present (odds ratio = 4.6 [1.1-19.3]) psychiatric diagnoses as compared to their non-RBD controls, but did not demonstrate a statistically significant difference in antidepressant use. There were otherwise no significant intergroup or intragroup differences with respect to the other assessed variables. Conclusions: Although causality cannot be inferred, numerous implications can be entertained, particularly in the early-onset group, including direct or indirect correlations with medication use and/or psychopathology and the development of RBD. The relatively high number of females in the early-onset group suggests a unique clinical profile for a condition typically characterized as male-predominant.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalSleep Medicine
Volume10
Issue number1
DOIs
StatePublished - Jan 2009

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Ocular Motility Disorders
REM Sleep
Age of Onset
Mental Disorders
Antidepressive Agents
Odds Ratio
Psychopathology
Causality
Sleep Wake Disorders

Keywords

  • Antidepressants
  • Idiopathic RBD
  • Medications
  • Psychiatric diagnoses
  • Rapid-eye-movement (REM) sleep behavior disorder (RBD)
  • Substances

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Idiopathic rapid-eye-movement sleep disorder : Associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset. / Teman, Paul T.; Tippmann-Peikert, Maja; Silber, Michael H.; Slocumb, Nancy L.; Auger, Robert R.

In: Sleep Medicine, Vol. 10, No. 1, 01.2009, p. 60-65.

Research output: Contribution to journalArticle

Teman, Paul T. ; Tippmann-Peikert, Maja ; Silber, Michael H. ; Slocumb, Nancy L. ; Auger, Robert R. / Idiopathic rapid-eye-movement sleep disorder : Associations with antidepressants, psychiatric diagnoses, and other factors, in relation to age of onset. In: Sleep Medicine. 2009 ; Vol. 10, No. 1. pp. 60-65.
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abstract = "Background: A retrospective, case-control chart review was performed to examine the relationship between the age of onset of idiopathic RBD and secondary associations. Methods: Forty-eight idiopathic RBD patients were divided into early-onset and late-onset groups, compared to each other, and to their respective non-RBD controls. Results: There were more females in the early-onset group as compared to their older counterparts (45{\%} vs. 11{\%}, p = 0.007). Early-onset patients also had significantly more past and present psychiatric diagnoses [85{\%} (both categories) vs. 46{\%} and 36{\%}, respectively, p < 0.01 for both comparisons] and antidepressant use (80{\%} vs. 46{\%}, p = 0.02) than the late-onset group. In comparison to non-RBD controls, early-onset patients again exhibited more psychiatric diagnoses (odds ratio = 17.0 [3.5-83.4], equivalent for past and present diagnoses) and antidepressant use (odds ratio = 12.0 [2.7-53.3]). Late-onset patients also had a higher frequency of past (odds ratio = 7.2 [1.8-29.6]) and present (odds ratio = 4.6 [1.1-19.3]) psychiatric diagnoses as compared to their non-RBD controls, but did not demonstrate a statistically significant difference in antidepressant use. There were otherwise no significant intergroup or intragroup differences with respect to the other assessed variables. Conclusions: Although causality cannot be inferred, numerous implications can be entertained, particularly in the early-onset group, including direct or indirect correlations with medication use and/or psychopathology and the development of RBD. The relatively high number of females in the early-onset group suggests a unique clinical profile for a condition typically characterized as male-predominant.",
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AB - Background: A retrospective, case-control chart review was performed to examine the relationship between the age of onset of idiopathic RBD and secondary associations. Methods: Forty-eight idiopathic RBD patients were divided into early-onset and late-onset groups, compared to each other, and to their respective non-RBD controls. Results: There were more females in the early-onset group as compared to their older counterparts (45% vs. 11%, p = 0.007). Early-onset patients also had significantly more past and present psychiatric diagnoses [85% (both categories) vs. 46% and 36%, respectively, p < 0.01 for both comparisons] and antidepressant use (80% vs. 46%, p = 0.02) than the late-onset group. In comparison to non-RBD controls, early-onset patients again exhibited more psychiatric diagnoses (odds ratio = 17.0 [3.5-83.4], equivalent for past and present diagnoses) and antidepressant use (odds ratio = 12.0 [2.7-53.3]). Late-onset patients also had a higher frequency of past (odds ratio = 7.2 [1.8-29.6]) and present (odds ratio = 4.6 [1.1-19.3]) psychiatric diagnoses as compared to their non-RBD controls, but did not demonstrate a statistically significant difference in antidepressant use. There were otherwise no significant intergroup or intragroup differences with respect to the other assessed variables. Conclusions: Although causality cannot be inferred, numerous implications can be entertained, particularly in the early-onset group, including direct or indirect correlations with medication use and/or psychopathology and the development of RBD. The relatively high number of females in the early-onset group suggests a unique clinical profile for a condition typically characterized as male-predominant.

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