Idiopathic nonspecific interstitial pneumonia/fibrosis: Comparison with idiopathic pulmonary fibrosis and BOOP

S. Nagai, M. Kitaichi, H. Itoh, K. Nishimura, T. Izumi, T. V. Colby

Research output: Contribution to journalArticle

324 Citations (Scopus)

Abstract

Based on past difficulties in clinically differentiating patients with idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans-organizing pneumonia (BOOP), and nonspecific interstitial pneumonia/fibrosis (NSIP), which all manifest clinically as interstitial lung disease, experience with pathologically confirmed examples of the three diseases was reviewed to compare clinical profiles and prognosis and to define NSIP more clearly. Thirty-one patients (15 males and 16 females) were pathologically identified as NSIP and subclassified into either the cellular (n=16) or fibrotic group (n=15). All 31 patients were clinically considered to be idiopathic NSIP cases. Patients with idiopathic BOOP (n=16) and IPF (n=64) were compared with the NSIP patients. Subacute presentation of interstitial lung disease characterized both idiopathic NSIP and idiopathic BOOP. NSIP patients showed volume loss on a chest radiograph (29.0%) and honeycombing on a computed tomography scan (25.8%); these features were not found in BOOP patients. Bronchoalveolar lavage lymphocytosis was characteristic of both BOOP and NSIP. Two subgroups of NSIP can be recognized histologically: patients in the fibrotic group had a less favourable outcome than those in the cellular group. BOOP and NSIP had a more favourable outcome than IPF. In conclusion, idiopathic nonspecific interstitial pneumonia can be differentiated from other types of idiopathic interstitial pneumonia, both pathologically and clinically.

Original languageEnglish (US)
Pages (from-to)1010-1019
Number of pages10
JournalEuropean Respiratory Journal
Volume12
Issue number5
StatePublished - Nov 1998

Fingerprint

Idiopathic Interstitial Pneumonias
Cryptogenic Organizing Pneumonia
Idiopathic Pulmonary Fibrosis
Interstitial Lung Diseases
Fibrosis
Lymphocytosis
Bronchoalveolar Lavage
Thorax

Keywords

  • Bronchiolitis obliterans-organizing pneumonia
  • Idiopathic interstitial pneumonia
  • Idiopathic pulmonary fibrosis
  • Nonspecific interstitial pneumonia/fibrosis
  • Surgical lung biopsy
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Nagai, S., Kitaichi, M., Itoh, H., Nishimura, K., Izumi, T., & Colby, T. V. (1998). Idiopathic nonspecific interstitial pneumonia/fibrosis: Comparison with idiopathic pulmonary fibrosis and BOOP. European Respiratory Journal, 12(5), 1010-1019.

Idiopathic nonspecific interstitial pneumonia/fibrosis : Comparison with idiopathic pulmonary fibrosis and BOOP. / Nagai, S.; Kitaichi, M.; Itoh, H.; Nishimura, K.; Izumi, T.; Colby, T. V.

In: European Respiratory Journal, Vol. 12, No. 5, 11.1998, p. 1010-1019.

Research output: Contribution to journalArticle

Nagai, S, Kitaichi, M, Itoh, H, Nishimura, K, Izumi, T & Colby, TV 1998, 'Idiopathic nonspecific interstitial pneumonia/fibrosis: Comparison with idiopathic pulmonary fibrosis and BOOP', European Respiratory Journal, vol. 12, no. 5, pp. 1010-1019.
Nagai, S. ; Kitaichi, M. ; Itoh, H. ; Nishimura, K. ; Izumi, T. ; Colby, T. V. / Idiopathic nonspecific interstitial pneumonia/fibrosis : Comparison with idiopathic pulmonary fibrosis and BOOP. In: European Respiratory Journal. 1998 ; Vol. 12, No. 5. pp. 1010-1019.
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