TY - JOUR
T1 - Idiopathic nonspecific interstitial pneumonia
T2 - Changes in high-resolution computed tomography on long-term follow-up
AU - Kim, Mi Young
AU - Song, Jin Woo
AU - Do, Kyung Hyun
AU - Jang, Se Jin
AU - Colby, Thomas V.
AU - Kim, Dong Soon
PY - 2012
Y1 - 2012
N2 - OBJECTIVE: This study aimed to assess the change in findings of nonspecific interstitial pneumonia (NSIP) from high-resolution computed tomography (HRCT) on long-term follow-up (median, 38 months). MATERIALS AND METHODS: A retrospective review of changes in HRCT in 68 patients with NSIP (fibrotic progression, 61) with follow-up HRCT of at least 1-year interval was conducted. RESULTS: Follow-up HRCT findings showed a decreased extent of ground-glass opacity and consolidation, with increased honeycombing, traction bronchiectasis, and architectural distortion (all P < 0.05). Radiological improvement was seen in 36%, stability was seen in 23%, and fibrotic progression was seen with recurrence in 13% and without recurrence in 28%. In 3 patients (4.9%), HRCT converted to a definite usual interstitial pneumonia pattern. Honeycombing and reticulation were independent predictors for mortality in fibrotic NSIP (P < 0.01). CONCLUSIONS: Although most of the follow-up HRCT scans showed improvement in the extent of ground-glass opacity and consolidation, approximately one third showed fibrotic progression or recurrence, with transition from NSIP to definite usual interstitial pneumonia pattern.
AB - OBJECTIVE: This study aimed to assess the change in findings of nonspecific interstitial pneumonia (NSIP) from high-resolution computed tomography (HRCT) on long-term follow-up (median, 38 months). MATERIALS AND METHODS: A retrospective review of changes in HRCT in 68 patients with NSIP (fibrotic progression, 61) with follow-up HRCT of at least 1-year interval was conducted. RESULTS: Follow-up HRCT findings showed a decreased extent of ground-glass opacity and consolidation, with increased honeycombing, traction bronchiectasis, and architectural distortion (all P < 0.05). Radiological improvement was seen in 36%, stability was seen in 23%, and fibrotic progression was seen with recurrence in 13% and without recurrence in 28%. In 3 patients (4.9%), HRCT converted to a definite usual interstitial pneumonia pattern. Honeycombing and reticulation were independent predictors for mortality in fibrotic NSIP (P < 0.01). CONCLUSIONS: Although most of the follow-up HRCT scans showed improvement in the extent of ground-glass opacity and consolidation, approximately one third showed fibrotic progression or recurrence, with transition from NSIP to definite usual interstitial pneumonia pattern.
KW - lung computed tomography
KW - nonspecific interstitial pneumonia
KW - usual interstitial fibrosis
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UR - http://www.scopus.com/inward/citedby.url?scp=84859176273&partnerID=8YFLogxK
U2 - 10.1097/RCT.0b013e31823ed437
DO - 10.1097/RCT.0b013e31823ed437
M3 - Article
C2 - 22446354
AN - SCOPUS:84859176273
SN - 0363-8715
VL - 36
SP - 170
EP - 174
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 2
ER -