Idiopathic nodular glomerulosclerosis in Chinese patients: a clinicopathologic study of 20 cases

Jun Wu, Shengqiang Yu, Vickram Tejwani, Michael Mao, Angela K. Muriithi, Chaoyang Ye, Xuezhi Zhao, Hongchen Gu, Changlin Mei, Qi Qian

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Results: All kidney biopsy specimens (3,480) were examined. After excluding specimens from patients with diabetes, fasting hyperglycemia or hemoglobin A1c elevation and other known entities associated with nodular glomerulosclerosis, 20 ING cases (1 in 174 biopsies) were identified. Patients with ING had a median age of 55.5 years, 16 (80 %) were male, 19 (95 %) had a body mass index (BMI) ≥25 kg/m2 [BMI ≥30 in 8 (40 %)], 18 (90 %) were hypertensive, 17 (85 %) had a history of cigarette smoking (mean pack-years 19.8 ± 2.4), and 10 (50 %) had hyperlipidemia. All 20 patients had >1 g/day proteinuria with a mean of 2.85 ± 0.33 g/day (seven had nephrotic-range proteinuria). Mean serum creatinine at the time of kidney biopsy was 4.23 ± 0.53 mg/dL (338.2 ± 44.7 μmol/L). Histopathologically, all specimens showed varying degrees of nodular glomerulosclerosis, glomerular basement membrane thickening, foot process effacement, interstitial fibrosis and arterial hyalinosis/sclerosis. Immunofluorescence was non-specific. At follow-up of 22.1 ± 1.15 days post-biopsy, six patients had developed end-stage renal failure and five had worsening serum creatinine concentrations not requiring dialysis.

Conclusion: ING is rare and appears to be associated with overweight, hypertension and cigarette smoking in Chinese patients.

Background: The objective of this study is to investigate the frequency and clinicopathological features of idiopathic nodular glomerulosclerosis (ING) in Chinese patients, on which there has been no previously published information.

Methods: Native kidney biopsies performed at a kidney histopathological center in Shanghai between January 1, 2009 and December 31, 2011 were retrospectively examined and relevant clinical data were reviewed.

Original languageEnglish (US)
Pages (from-to)865-875
Number of pages11
JournalClinical and Experimental Nephrology
Volume18
Issue number6
DOIs
StatePublished - Jan 1 2014

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Diabetic Nephropathies
Biopsy
Kidney
Proteinuria
Creatinine
Smoking
Glomerular Basement Membrane
Sclerosis
Hyperlipidemias
Serum
Hyperglycemia
Chronic Kidney Failure
Fluorescent Antibody Technique
Foot
Dialysis
Fasting
Hemoglobins
Body Mass Index
Fibrosis
Hypertension

Keywords

  • Chronic renal disease
  • Hypertension
  • Nodular glomerulosclerosis
  • Obesity
  • Proteinuria
  • Smoking

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Idiopathic nodular glomerulosclerosis in Chinese patients : a clinicopathologic study of 20 cases. / Wu, Jun; Yu, Shengqiang; Tejwani, Vickram; Mao, Michael; Muriithi, Angela K.; Ye, Chaoyang; Zhao, Xuezhi; Gu, Hongchen; Mei, Changlin; Qian, Qi.

In: Clinical and Experimental Nephrology, Vol. 18, No. 6, 01.01.2014, p. 865-875.

Research output: Contribution to journalArticle

Wu, Jun ; Yu, Shengqiang ; Tejwani, Vickram ; Mao, Michael ; Muriithi, Angela K. ; Ye, Chaoyang ; Zhao, Xuezhi ; Gu, Hongchen ; Mei, Changlin ; Qian, Qi. / Idiopathic nodular glomerulosclerosis in Chinese patients : a clinicopathologic study of 20 cases. In: Clinical and Experimental Nephrology. 2014 ; Vol. 18, No. 6. pp. 865-875.
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abstract = "Results: All kidney biopsy specimens (3,480) were examined. After excluding specimens from patients with diabetes, fasting hyperglycemia or hemoglobin A1c elevation and other known entities associated with nodular glomerulosclerosis, 20 ING cases (1 in 174 biopsies) were identified. Patients with ING had a median age of 55.5 years, 16 (80 {\%}) were male, 19 (95 {\%}) had a body mass index (BMI) ≥25 kg/m2 [BMI ≥30 in 8 (40 {\%})], 18 (90 {\%}) were hypertensive, 17 (85 {\%}) had a history of cigarette smoking (mean pack-years 19.8 ± 2.4), and 10 (50 {\%}) had hyperlipidemia. All 20 patients had >1 g/day proteinuria with a mean of 2.85 ± 0.33 g/day (seven had nephrotic-range proteinuria). Mean serum creatinine at the time of kidney biopsy was 4.23 ± 0.53 mg/dL (338.2 ± 44.7 μmol/L). Histopathologically, all specimens showed varying degrees of nodular glomerulosclerosis, glomerular basement membrane thickening, foot process effacement, interstitial fibrosis and arterial hyalinosis/sclerosis. Immunofluorescence was non-specific. At follow-up of 22.1 ± 1.15 days post-biopsy, six patients had developed end-stage renal failure and five had worsening serum creatinine concentrations not requiring dialysis.Conclusion: ING is rare and appears to be associated with overweight, hypertension and cigarette smoking in Chinese patients.Background: The objective of this study is to investigate the frequency and clinicopathological features of idiopathic nodular glomerulosclerosis (ING) in Chinese patients, on which there has been no previously published information.Methods: Native kidney biopsies performed at a kidney histopathological center in Shanghai between January 1, 2009 and December 31, 2011 were retrospectively examined and relevant clinical data were reviewed.",
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AU - Wu, Jun

AU - Yu, Shengqiang

AU - Tejwani, Vickram

AU - Mao, Michael

AU - Muriithi, Angela K.

AU - Ye, Chaoyang

AU - Zhao, Xuezhi

AU - Gu, Hongchen

AU - Mei, Changlin

AU - Qian, Qi

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N2 - Results: All kidney biopsy specimens (3,480) were examined. After excluding specimens from patients with diabetes, fasting hyperglycemia or hemoglobin A1c elevation and other known entities associated with nodular glomerulosclerosis, 20 ING cases (1 in 174 biopsies) were identified. Patients with ING had a median age of 55.5 years, 16 (80 %) were male, 19 (95 %) had a body mass index (BMI) ≥25 kg/m2 [BMI ≥30 in 8 (40 %)], 18 (90 %) were hypertensive, 17 (85 %) had a history of cigarette smoking (mean pack-years 19.8 ± 2.4), and 10 (50 %) had hyperlipidemia. All 20 patients had >1 g/day proteinuria with a mean of 2.85 ± 0.33 g/day (seven had nephrotic-range proteinuria). Mean serum creatinine at the time of kidney biopsy was 4.23 ± 0.53 mg/dL (338.2 ± 44.7 μmol/L). Histopathologically, all specimens showed varying degrees of nodular glomerulosclerosis, glomerular basement membrane thickening, foot process effacement, interstitial fibrosis and arterial hyalinosis/sclerosis. Immunofluorescence was non-specific. At follow-up of 22.1 ± 1.15 days post-biopsy, six patients had developed end-stage renal failure and five had worsening serum creatinine concentrations not requiring dialysis.Conclusion: ING is rare and appears to be associated with overweight, hypertension and cigarette smoking in Chinese patients.Background: The objective of this study is to investigate the frequency and clinicopathological features of idiopathic nodular glomerulosclerosis (ING) in Chinese patients, on which there has been no previously published information.Methods: Native kidney biopsies performed at a kidney histopathological center in Shanghai between January 1, 2009 and December 31, 2011 were retrospectively examined and relevant clinical data were reviewed.

AB - Results: All kidney biopsy specimens (3,480) were examined. After excluding specimens from patients with diabetes, fasting hyperglycemia or hemoglobin A1c elevation and other known entities associated with nodular glomerulosclerosis, 20 ING cases (1 in 174 biopsies) were identified. Patients with ING had a median age of 55.5 years, 16 (80 %) were male, 19 (95 %) had a body mass index (BMI) ≥25 kg/m2 [BMI ≥30 in 8 (40 %)], 18 (90 %) were hypertensive, 17 (85 %) had a history of cigarette smoking (mean pack-years 19.8 ± 2.4), and 10 (50 %) had hyperlipidemia. All 20 patients had >1 g/day proteinuria with a mean of 2.85 ± 0.33 g/day (seven had nephrotic-range proteinuria). Mean serum creatinine at the time of kidney biopsy was 4.23 ± 0.53 mg/dL (338.2 ± 44.7 μmol/L). Histopathologically, all specimens showed varying degrees of nodular glomerulosclerosis, glomerular basement membrane thickening, foot process effacement, interstitial fibrosis and arterial hyalinosis/sclerosis. Immunofluorescence was non-specific. At follow-up of 22.1 ± 1.15 days post-biopsy, six patients had developed end-stage renal failure and five had worsening serum creatinine concentrations not requiring dialysis.Conclusion: ING is rare and appears to be associated with overweight, hypertension and cigarette smoking in Chinese patients.Background: The objective of this study is to investigate the frequency and clinicopathological features of idiopathic nodular glomerulosclerosis (ING) in Chinese patients, on which there has been no previously published information.Methods: Native kidney biopsies performed at a kidney histopathological center in Shanghai between January 1, 2009 and December 31, 2011 were retrospectively examined and relevant clinical data were reviewed.

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KW - Hypertension

KW - Nodular glomerulosclerosis

KW - Obesity

KW - Proteinuria

KW - Smoking

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