Idiopathic inflammatory myopathy of the antisynthetase (jo‐1) type associated with noncaseating granulomas

Kevin G. Moder, Thomas A. Gaffey, Eric L. Matteson

Research output: Contribution to journalArticle

11 Scopus citations


The idiopathic inflammatory myopathies are a heterogeneous group of syndromes that share the finding of chronic muscle inflammation. Recently, serologic subtyping of autoantibodies found in patients with these syndromes has been used to identify distinct clinical entities. We describe a 36‐year‐old woman who, based on the findings of polymyositis documented by both electromyography and muscle biopsy, features of Raynaud's phenomenon, symmetric polyarthritis, “mechanic's hands,” and Jo‐1 antibody positivity, was considered to have the antisynthetase subset of idiopathic inflammatory myopathy. In addition, the patient had granulomatous synovitis, and noncaseating granulomas were found in a breast nodule. This is the first published report of granuloma formation in the antisynthetase syndrome.

Original languageEnglish (US)
Pages (from-to)1743-1747
Number of pages5
JournalArthritis & Rheumatism
Issue number12
StatePublished - Dec 1993


ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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