Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease

Wojciech C. Blonski, David A Katzka, Gary R. Lichtenstein, David C. Metz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Many gastric acid hypersecretory states (basal acid output of greater than 15.0 mEq/h) exist for which the etiology is known, such as Zollinger-Ellison syndrome, systemic mastocytosis, antral exclusion, antral predominant Helicobacter pylori gastritis (antral G cell hyperplasia), chronic gastric outlet obstruction, short gut syndrome and basophilic leukemias. However, many hypersecretory patients have no identified etiology for their acid hypersecretion and are designated as idiopathic gastric acid hypersecretors with a basal acid output of greater than 10 mEq/h and a normal serum gastrin level. Because of the gastric acid hypersecretion these patients also commonly have an increased frequency of stools. Idiopathic gastric acid hypersecretion represents a known cause of gastric acid hypersecretion that is far more common than Zollinger-Ellison syndrome and it has a markedly different treatment regimen and natural history. We report a case of a patient with idiopathic gastric acid hypersecretion previously misdiagnosed as having Crohn's disease because of a presenting complaint of diarrhea and mimicking Zollinger-Ellison syndrome because her fasting serum gastrin level was elevated when incorrectly measured in the presence of antisecretory treatment.

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume17
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Zollinger-Ellison Syndrome
Gastric Acid
Crohn Disease
Gastrins
Acids
Systemic Mastocytosis
Gastric Outlet Obstruction
Gastrin-Secreting Cells
Gastritis
Diagnostic Errors
Natural History
Serum
Helicobacter pylori
Hyperplasia
Diarrhea
Fasting
Leukemia
Therapeutics
Antral

Keywords

  • Basal acid output
  • Crohn's disease
  • Idiopathic gastric acid hypersecretion
  • Zollinger-Ellison syndrome

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Idiopathic gastric acid hypersecretion presenting as a diarrheal disorder and mimicking both Zollinger-Ellison syndrome and Crohn's disease. / Blonski, Wojciech C.; Katzka, David A; Lichtenstein, Gary R.; Metz, David C.

In: European Journal of Gastroenterology and Hepatology, Vol. 17, No. 4, 04.2005, p. 441-444.

Research output: Contribution to journalArticle

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