'Idiopathic' eosinophilia with an Occult T-cell clone: Prevalence and clinical course

C. Vaklavas; A. Tefferi; J. Butterfield; R. Ketterling; S. Verstovsek; H. Kantarjian; A. Pardanani

doi:10.1016/j.leukres.2006.10.005

'Idiopathic' eosinophilia with an Occult T-cell clone: Prevalence and clinical course

C. Vaklavas, A. Tefferi, J. Butterfield, R. Ketterling, S. Verstovsek, H. Kantarjian, A. Pardanani

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

In a study of 99 consecutive patients with 'idiopathic' eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (∼8%) with an 'Occult' T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec^® treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.

Original language	English (US)
Pages (from-to)	691-694
Number of pages	4
Journal	Leukemia Research
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.leukres.2006.10.005
State	Published - May 2007

Keywords

Eosinophilia
FIP1L1-PDGFRA
T-cells

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/j.leukres.2006.10.005

Cite this

@article{c9734e07dd7a496ebde80398fa8bacfa,

title = "'Idiopathic' eosinophilia with an Occult T-cell clone: Prevalence and clinical course",

abstract = "In a study of 99 consecutive patients with 'idiopathic' eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (∼8%) with an 'Occult' T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec{\textregistered} treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.",

keywords = "Eosinophilia, FIP1L1-PDGFRA, T-cells",

author = "C. Vaklavas and A. Tefferi and J. Butterfield and R. Ketterling and S. Verstovsek and H. Kantarjian and A. Pardanani",

year = "2007",

month = may,

doi = "10.1016/j.leukres.2006.10.005",

language = "English (US)",

volume = "31",

pages = "691--694",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "5",

}

TY - JOUR

T1 - 'Idiopathic' eosinophilia with an Occult T-cell clone

T2 - Prevalence and clinical course

AU - Vaklavas, C.

AU - Tefferi, A.

AU - Butterfield, J.

AU - Ketterling, R.

AU - Verstovsek, S.

AU - Kantarjian, H.

AU - Pardanani, A.

PY - 2007/5

Y1 - 2007/5

N2 - In a study of 99 consecutive patients with 'idiopathic' eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (∼8%) with an 'Occult' T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec® treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.

AB - In a study of 99 consecutive patients with 'idiopathic' eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (∼8%) with an 'Occult' T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec® treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.

KW - Eosinophilia

KW - FIP1L1-PDGFRA

KW - T-cells

UR - http://www.scopus.com/inward/record.url?scp=34147117108&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34147117108&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2006.10.005

DO - 10.1016/j.leukres.2006.10.005

M3 - Article

C2 - 17095087

AN - SCOPUS:34147117108

SN - 0145-2126

VL - 31

SP - 691

EP - 694

JO - Leukemia Research

JF - Leukemia Research

IS - 5

ER -

'Idiopathic' eosinophilia with an Occult T-cell clone: Prevalence and clinical course

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this