'Idiopathic' eosinophilia with an Occult T-cell clone: Prevalence and clinical course

C. Vaklavas, A. Tefferi, J. Butterfield, R. Ketterling, S. Verstovsek, H. Kantarjian, A. Pardanani

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

In a study of 99 consecutive patients with 'idiopathic' eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (∼8%) with an 'Occult' T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec® treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalLeukemia Research
Volume31
Issue number5
DOIs
StatePublished - May 1 2007

Keywords

  • Eosinophilia
  • FIP1L1-PDGFRA
  • T-cells

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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