Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene

Nicholaus J. Hilliard, Irfan A. Warraich, Rachael Kruspe, Belinda Hyche, James Foran, Vishnu V.B. Reddy

Research output: Contribution to journalArticle

Abstract

Charcot Leyden crystals in the bone marrow are rare and have been described in the bone marrow1,5,11 and in the soft tissue2 (granulocytic sarcoma); however, no consistent cytogenetic abnormality has been associated. Charcot Leyden crystals are seen in fluids and tissues with eosinophilic dominated inflammatory reactions. To date, eosinophilic associated chronic myelomonocytic leukemia (CMML-2) has not been described with Charcot Leyden crystals. Recent exciting cytogenetic associations have linked idiopathic eosinophilia to myelodysplastic and myeloproliferative syndromes and in particular certain genes (ie, PDGFRbeta ETV6 fusion, FIPIL1-PDGFRalpha fusion, and others). We describe a case of idiopathic eosinophilia with Charcot Leyden crystals associated with CMML-2 and overexpression of ETV6.

Original languageEnglish (US)
Pages (from-to)100-102
Number of pages3
JournalLaboratory medicine
Volume38
Issue number2
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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    Hilliard, N. J., Warraich, I. A., Kruspe, R., Hyche, B., Foran, J., & Reddy, V. V. B. (2007). Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene. Laboratory medicine, 38(2), 100-102. https://doi.org/10.1309/NK016KM49XQ2H17X