Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene

Nicholaus J. Hilliard; Irfan A. Warraich; Rachael Kruspe; Belinda Hyche; James Foran; Vishnu V.B. Reddy

doi:10.1309/NK016KM49XQ2H17X

Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene

Nicholaus J. Hilliard, Irfan A. Warraich, Rachael Kruspe, Belinda Hyche, James Foran, Vishnu V.B. Reddy

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

Abstract

Charcot Leyden crystals in the bone marrow are rare and have been described in the bone marrow^1,5,11 and in the soft tissue² (granulocytic sarcoma); however, no consistent cytogenetic abnormality has been associated. Charcot Leyden crystals are seen in fluids and tissues with eosinophilic dominated inflammatory reactions. To date, eosinophilic associated chronic myelomonocytic leukemia (CMML-2) has not been described with Charcot Leyden crystals. Recent exciting cytogenetic associations have linked idiopathic eosinophilia to myelodysplastic and myeloproliferative syndromes and in particular certain genes (ie, PDGFRbeta ETV6 fusion, FIPIL1-PDGFRalpha fusion, and others). We describe a case of idiopathic eosinophilia with Charcot Leyden crystals associated with CMML-2 and overexpression of ETV6.

Original language	English (US)
Pages (from-to)	100-102
Number of pages	3
Journal	Laboratory medicine
Volume	38
Issue number	2
DOIs	https://doi.org/10.1309/NK016KM49XQ2H17X
State	Published - 2007

ASJC Scopus subject areas

Medicine(all)

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10.1309/NK016KM49XQ2H17X

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title = "Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene",

abstract = "Charcot Leyden crystals in the bone marrow are rare and have been described in the bone marrow1,5,11 and in the soft tissue2 (granulocytic sarcoma); however, no consistent cytogenetic abnormality has been associated. Charcot Leyden crystals are seen in fluids and tissues with eosinophilic dominated inflammatory reactions. To date, eosinophilic associated chronic myelomonocytic leukemia (CMML-2) has not been described with Charcot Leyden crystals. Recent exciting cytogenetic associations have linked idiopathic eosinophilia to myelodysplastic and myeloproliferative syndromes and in particular certain genes (ie, PDGFRbeta ETV6 fusion, FIPIL1-PDGFRalpha fusion, and others). We describe a case of idiopathic eosinophilia with Charcot Leyden crystals associated with CMML-2 and overexpression of ETV6.",

author = "Hilliard, {Nicholaus J.} and Warraich, {Irfan A.} and Rachael Kruspe and Belinda Hyche and James Foran and Reddy, {Vishnu V.B.}",

year = "2007",

doi = "10.1309/NK016KM49XQ2H17X",

language = "English (US)",

volume = "38",

pages = "100--102",

journal = "Laboratory Medicine",

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publisher = "American Society of Clinical Pathologists",

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TY - JOUR

T1 - Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene

AU - Hilliard, Nicholaus J.

AU - Warraich, Irfan A.

AU - Kruspe, Rachael

AU - Hyche, Belinda

AU - Foran, James

AU - Reddy, Vishnu V.B.

PY - 2007

Y1 - 2007

N2 - Charcot Leyden crystals in the bone marrow are rare and have been described in the bone marrow1,5,11 and in the soft tissue2 (granulocytic sarcoma); however, no consistent cytogenetic abnormality has been associated. Charcot Leyden crystals are seen in fluids and tissues with eosinophilic dominated inflammatory reactions. To date, eosinophilic associated chronic myelomonocytic leukemia (CMML-2) has not been described with Charcot Leyden crystals. Recent exciting cytogenetic associations have linked idiopathic eosinophilia to myelodysplastic and myeloproliferative syndromes and in particular certain genes (ie, PDGFRbeta ETV6 fusion, FIPIL1-PDGFRalpha fusion, and others). We describe a case of idiopathic eosinophilia with Charcot Leyden crystals associated with CMML-2 and overexpression of ETV6.

AB - Charcot Leyden crystals in the bone marrow are rare and have been described in the bone marrow1,5,11 and in the soft tissue2 (granulocytic sarcoma); however, no consistent cytogenetic abnormality has been associated. Charcot Leyden crystals are seen in fluids and tissues with eosinophilic dominated inflammatory reactions. To date, eosinophilic associated chronic myelomonocytic leukemia (CMML-2) has not been described with Charcot Leyden crystals. Recent exciting cytogenetic associations have linked idiopathic eosinophilia to myelodysplastic and myeloproliferative syndromes and in particular certain genes (ie, PDGFRbeta ETV6 fusion, FIPIL1-PDGFRalpha fusion, and others). We describe a case of idiopathic eosinophilia with Charcot Leyden crystals associated with CMML-2 and overexpression of ETV6.

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JO - Laboratory Medicine

JF - Laboratory Medicine

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Idiopathic eosinophilia associated CMML-2 with overexpression of the ETV6 gene

Abstract

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