Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma

E. S. Baskin-Bey, H. C. Devarbhavi, D. M. Nagorney, M. B. Farnell, J. H. Donohue, S. O. Sanderson, L. M. Stadheim, Gregory James Gores

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective. Distinguishing between malignant and benign biliary strictures remains problematic. The aim of this study was to compare and contrast the clinical features of patients with benign and m alignant biliary strictures. Methods. Medical records of patients who underwent surgical resection for presumed cholangiocarcinoma were reviewed. Immunohistochemistry for hypoxia inducible factor-1-alpha (HIF-1-alpha) was performed on all bile ductule samples. Results. Twelve patients with benign strictures (group I) were compared to 26 patients with cholangiocarcinoma (group II). Group I was predominantly female (ratio 2:1), (p<0.01), whereas the gender ratio was 1:1 in patients in group II. Bismuth-Corlette type strictures in group I were more likely to be type I/II, whereas type III strictures predominated in group II. The CA 19-9 was <100 U/ml in 6 and >100 U/ml in 1 patient of group I and >100 in 13 and <100 in 11 patients in group II. Half of the patients in group I had positive immunoreactivity for HIF-1-alpha in bile ductules. Conclusion. Benign biliary strictures masquerading as cholangiocarcinomas occur more often in women, are less often Bismuth-Corlette type III, have serum CA 19-9 values <100 U/ml, and hypoxia may play a role in a subset of these strictures.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalHPB
Volume7
Issue number4
DOIs
StatePublished - 2005

Fingerprint

Cholangiocarcinoma
Pathologic Constriction
Hypoxia-Inducible Factor 1
Bile
Bismuth
Medical Records
Immunohistochemistry
Serum

Keywords

  • Bile duct strictures
  • Cholangiocarcinoma
  • HIF-1-alpha
  • Sarcoidosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Baskin-Bey, E. S., Devarbhavi, H. C., Nagorney, D. M., Farnell, M. B., Donohue, J. H., Sanderson, S. O., ... Gores, G. J. (2005). Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma. HPB, 7(4), 283-288. https://doi.org/10.1080/13651820500292954

Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma. / Baskin-Bey, E. S.; Devarbhavi, H. C.; Nagorney, D. M.; Farnell, M. B.; Donohue, J. H.; Sanderson, S. O.; Stadheim, L. M.; Gores, Gregory James.

In: HPB, Vol. 7, No. 4, 2005, p. 283-288.

Research output: Contribution to journalArticle

Baskin-Bey, ES, Devarbhavi, HC, Nagorney, DM, Farnell, MB, Donohue, JH, Sanderson, SO, Stadheim, LM & Gores, GJ 2005, 'Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma', HPB, vol. 7, no. 4, pp. 283-288. https://doi.org/10.1080/13651820500292954
Baskin-Bey ES, Devarbhavi HC, Nagorney DM, Farnell MB, Donohue JH, Sanderson SO et al. Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma. HPB. 2005;7(4):283-288. https://doi.org/10.1080/13651820500292954
Baskin-Bey, E. S. ; Devarbhavi, H. C. ; Nagorney, D. M. ; Farnell, M. B. ; Donohue, J. H. ; Sanderson, S. O. ; Stadheim, L. M. ; Gores, Gregory James. / Idiopathic benign biliary strictures in surgically resected patients with presumed cholangiocarcinoma. In: HPB. 2005 ; Vol. 7, No. 4. pp. 283-288.
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AB - Objective. Distinguishing between malignant and benign biliary strictures remains problematic. The aim of this study was to compare and contrast the clinical features of patients with benign and m alignant biliary strictures. Methods. Medical records of patients who underwent surgical resection for presumed cholangiocarcinoma were reviewed. Immunohistochemistry for hypoxia inducible factor-1-alpha (HIF-1-alpha) was performed on all bile ductule samples. Results. Twelve patients with benign strictures (group I) were compared to 26 patients with cholangiocarcinoma (group II). Group I was predominantly female (ratio 2:1), (p<0.01), whereas the gender ratio was 1:1 in patients in group II. Bismuth-Corlette type strictures in group I were more likely to be type I/II, whereas type III strictures predominated in group II. The CA 19-9 was <100 U/ml in 6 and >100 U/ml in 1 patient of group I and >100 in 13 and <100 in 11 patients in group II. Half of the patients in group I had positive immunoreactivity for HIF-1-alpha in bile ductules. Conclusion. Benign biliary strictures masquerading as cholangiocarcinomas occur more often in women, are less often Bismuth-Corlette type III, have serum CA 19-9 values <100 U/ml, and hypoxia may play a role in a subset of these strictures.

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