Identifying women with increased risk of breast cancer and implementing risk-reducing strategies and supplemental imaging

Suneela Vegunta, Asha A. Bhatt, Sadia Choudhery, Sandhya Pruthi, Aparna S. Kaur

Research output: Contribution to journalReview articlepeer-review

Abstract

Breast cancer (BC) is the second most common cancer in women, affecting 1 in 8 women in the United States (12.5%) in their lifetime. However, some women have a higher lifetime risk of BC because of genetic and lifestyle factors, mammographic breast density, and reproductive and hormonal factors. Because BC risk is variable, screening and prevention strategies should be individualized after considering patient-specific risk factors. Thus, health care professionals need to be able to assess risk profiles, identify high-risk women, and individualize screening and prevention strategies through a shared decision-making process. In this article, we review the risk factors for BC, risk-assessment models that identify high-risk patients, and preventive medications and lifestyle modifications that may decrease risk. We also discuss the benefits and limitations of various supplemental screening methods.

Original languageEnglish (US)
JournalBreast Cancer
DOIs
StateAccepted/In press - 2021

Keywords

  • BRCA
  • Breast MRI
  • Dense breast tissue
  • Risk factors for breast cancer
  • Risk-assessment models

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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